ENSMUSG00000020656


Mus musculus

Features
Gene ID: ENSMUSG00000020656
  
Biological name :Grhl1
  
Synonyms : Grainyhead-like / Grhl1 / Q921D9
  
Possible biological names infered from orthology : grainyhead like transcription factor 1 / Q9NZI5
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.3
Gene start: 24572283
Gene end: 24617391
  
Corresponding Affymetrix probe sets: 10394954 (MoGene1.0st)   1424030_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020985
Ensembl peptide - ENSMUSP00000082689
NCBI entrez gene - 195733     See in Manteia.
MGI - MGI:2182540
RefSeq - XM_017315004
RefSeq - NM_001161406
RefSeq - NM_145890
RefSeq - XM_006515016
RefSeq - XM_006515017
RefSeq Peptide - NP_001154878
RefSeq Peptide - NP_665897
swissprot - Q921D9
swissprot - E9QMF0
Ensembl - ENSMUSG00000020656
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grhl1ENSDARG00000061391Danio rerio
 GRHL1ENSGALG00000038495Gallus gallus
 GRHL1ENSG00000134317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grhl2 / Q8K5C0 / Grainyhead-like / Q6ISB3* / grainyhead like transcription factor 2*ENSMUSG0000002228658
Grhl3 / Q5FWH3 / Grainyhead-like / Q8TE85* / grainyhead like transcription factor 3*ENSMUSG0000003718845
Tfcp2 / Q9ERA0 / Mus musculus transcription factor CP2 (Tfcp2), transcript variant 3, mRNA. / Q12800* / transcription factor CP2*ENSMUSG0000000973320
Q3UNW5 / Tfcp2l1 / Transcription factor CP2-like protein 1 / Q9NZI6* / transcription factor CP2 like 1*ENSMUSG0000002638019
Ubp1 / Q811S7 / upstream binding protein 1 / Q9NZI7*ENSMUSG0000000974119


Protein motifs (from Interpro)
Interpro ID Name
 IPR007604  CP2 transcription factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002934 desmosome organization IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0061436 establishment of skin barrier IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Grhl1m1J/Grhl1m1J
Genetic Background: B6.Cg-Grhl1m1J/GrsrJ

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

Allelic Composition: Grhl1m1J/Grhl1m1J
Genetic Background: B6.Cg-Grhl1m1J/GrsrJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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