ENSMUSG00000026380


Mus musculus

Features
Gene ID: ENSMUSG00000026380
  
Biological name :Tfcp2l1
  
Synonyms : Q3UNW5 / Tfcp2l1 / Transcription factor CP2-like protein 1
  
Possible biological names infered from orthology : Q9NZI6 / transcription factor CP2 like 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E2.3
Gene start: 118627945
Gene end: 118685168
  
Corresponding Affymetrix probe sets: 10349295 (MoGene1.0st)   1418091_at (Mouse Genome 430 2.0 Array)   1460714_at (Mouse Genome 430 2.0 Array)   1460715_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027629
NCBI entrez gene - 81879     See in Manteia.
MGI - MGI:2444691
RefSeq - NM_023755
RefSeq - XM_006529961
RefSeq Peptide - NP_076244
swissprot - Q3UNW5
Ensembl - ENSMUSG00000026380
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfcp2l1ENSDARG00000029497Danio rerio
 TFCP2L1ENSGALG00000011635Gallus gallus
 Q9NZI6ENSG00000115112Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tfcp2 / Q9ERA0 / Mus musculus transcription factor CP2 (Tfcp2), transcript variant 3, mRNA. / Q12800* / transcription factor CP2*ENSMUSG0000000973371
Ubp1 / Q811S7 / upstream binding protein 1 / Q9NZI7*ENSMUSG0000000974166
Grhl3 / Q5FWH3 / Grainyhead-like / Q8TE85* / grainyhead like transcription factor 3*ENSMUSG0000003718825
Grhl1 / Q921D9 / Grainyhead-like / Q9NZI5* / grainyhead like transcription factor 1*ENSMUSG0000002065624
Grhl2 / Q8K5C0 / Grainyhead-like / Q6ISB3* / grainyhead like transcription factor 2*ENSMUSG0000002228624


Protein motifs (from Interpro)
Interpro ID Name
 IPR007604  CP2 transcription factor
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007028 cytoplasm organization IMP
 biological_processGO:0007431 salivary gland development IMP
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0045927 positive regulation of growth IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex ISA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0002163 abnormal gland morphology "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlg1tm1Taki/Dlg1tm1Taki
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0011754 abnormal kidney collecting duct intercalated cell morphology "any structural anomaly of any of the functionally distinct subtypes of cells (alpha or beta) found on the kidney collecting duct epithelium that regulate acid-base homeostasis and play an important role in the kidney s response to acidosis and alkalosis; alpha-intercalated cells secrete acid whereas beta-intercalated cells secrete base; metabolic acidosis results in the conversion of beta- cells to alpha-intercalated cells giving the kidney a greater ability to secrete protons and return pH to the normal range" [MGI:anna]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

 MP:0013580 abnormal nasal gland morphology "any structural anomaly of any of the seromucous glands found in the respiratory region of the nasal mucous membrane, including anterior serous glands, seromucous glands, and Bowman glands" [http://en.wikipedia.org/wiki/Nasal_glands, MGI:Anna, UBERON:0012278]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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