ENSMUSG00000037188


Mus musculus

Features
Gene ID: ENSMUSG00000037188
  
Biological name :Grhl3
  
Synonyms : Grainyhead-like / Grhl3 / Q5FWH3
  
Possible biological names infered from orthology : grainyhead like transcription factor 3 / Q8TE85
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 135541888
Gene end: 135573630
  
Corresponding Affymetrix probe sets: 10517401 (MoGene1.0st)   1436932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101481
NCBI entrez gene - 230824     See in Manteia.
MGI - MGI:2655333
RefSeq - NM_001013756
RefSeq - XM_006538760
RefSeq Peptide - NP_001013778
swissprot - Q5FWH3
Ensembl - ENSMUSG00000037188
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grhl3ENSDARG00000078552Danio rerio
 GRHL3ENSGALG00000004249Gallus gallus
 GRHL3ENSG00000158055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grhl2 / Q8K5C0 / Grainyhead-like / Q6ISB3* / grainyhead like transcription factor 2*ENSMUSG0000002228647
Grhl1 / Q921D9 / Grainyhead-like / Q9NZI5* / grainyhead like transcription factor 1*ENSMUSG0000002065646
Q3UNW5 / Tfcp2l1 / Transcription factor CP2-like protein 1 / Q9NZI6* / transcription factor CP2 like 1*ENSMUSG0000002638020
Tfcp2 / Q9ERA0 / Mus musculus transcription factor CP2 (Tfcp2), transcript variant 3, mRNA. / Q12800* / transcription factor CP2*ENSMUSG0000000973319
Ubp1 / Q811S7 / upstream binding protein 1 / Q9NZI7*ENSMUSG0000000974119


Protein motifs (from Interpro)
Interpro ID Name
 IPR007604  CP2 transcription factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IGI
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0043547 positive regulation of GTPase activity IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0061029 eyelid development in camera-type eye IMP
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+,Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3tm1(cre)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: STOCK Grhl3ct/J

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3tm1(cre)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3tm2.1(F2rl1)Cgh
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3tm1(cre)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx8tm1.1Hko/Cbx8tm1.1Hko
Genetic Background: Not Specified

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

Allelic Composition: Grhl3ct-J/Grhl3ct-J,mct1C57BL/6J/mct1C57BL/6J
Genetic Background: involves: BALB/cByJ * STOCK ct/J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: involves: CBA/Gr * GFF

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: involves: GFF

Allelic Composition: Grhl3ct/Grhl3+
Genetic Background: involves: C57BL/6 * GFF

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: STOCK Grhl3ct/J

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: involves: CBA/Gr * GFF

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: involves: GFF

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3tm1(cre)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grhl3tm2.1Jane/Grhl3tm2.1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ

Allelic Composition: Grhl3tm1Jane/Grhl3tm2.1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ

Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3tm2.1(F2rl1)Cgh
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: involves: GFF

Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0004603 absent vertebral arch "loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0004687 split vertebrae "any vertebrae or vertebral section that is cleft into two parts " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0009474 thick epidermal spinous layer "increased thickness of the stratum spinosum; the polyhedral cell layer" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+,Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0009929 meningomyelocele "hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Grhl1tm1Jane/Grhl1tm1Jane,Grhl3tm1Jane/Grhl3tm3.1Jane,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+,Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

Allelic Composition: Grhl3tm2.1(F2rl1)Cgh/Grhl3tm2.1(F2rl1)Cgh
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2Cgh/Gna13tm2Cgh,Grhl3tm1(cre)Cgh/Grhl3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+,Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grhl3tm2.1Jane/Grhl3tm2.1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ

Allelic Composition: Grhl3tm1Jane/Grhl3tm2.1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ

 MP:0012547 spina bifida cystica "spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection" [MGI:anna]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: STOCK Grhl3ct/J

 MP:0013531 abnormal periderm development "abnormal formation of the outermost layer of the bilaminar embryonic/fetal epidermis; periderm cells emerge at approximately E9.5 and form simple squamous epithelium, the most superficial embryonic layer; these cells form the first, but temporary, embryonic permeability barrier, and are replaced by the cornified envelope, that forms during keratinocyte stratification, by E16.5" [http://discovery.lifemapsc.com/in-vivo-development/epidermis/embryonic-epidermis/periderm-cells, MGI:Anna]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+,Irf6Gt(OST398253)Lex/Irf6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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