ENSMUSG00000022286


Mus musculus

Features
Gene ID: ENSMUSG00000022286
  
Biological name :Grhl2
  
Synonyms : Grainyhead-like / Grhl2 / Q8K5C0
  
Possible biological names infered from orthology : grainyhead like transcription factor 2 / Q6ISB3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 37233036
Gene end: 37363569
  
Corresponding Affymetrix probe sets: 10423770 (MoGene1.0st)   1427046_at (Mouse Genome 430 2.0 Array)   1431877_a_at (Mouse Genome 430 2.0 Array)   1431878_at (Mouse Genome 430 2.0 Array)   1452643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022895
Ensembl peptide - ENSMUSP00000123871
Ensembl peptide - ENSMUSP00000124903
Ensembl peptide - ENSMUSP00000125410
NCBI entrez gene - 252973     See in Manteia.
MGI - MGI:2182543
RefSeq - XM_017316623
RefSeq - NM_026496
RefSeq - XM_006520063
RefSeq - XM_006520065
RefSeq - XM_017316621
RefSeq - XM_017316622
RefSeq Peptide - NP_080772
swissprot - F6UT30
swissprot - F6TZV3
swissprot - Q8K5C0
swissprot - Q9DCN4
Ensembl - ENSMUSG00000022286
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grhl2aENSDARG00000058342Danio rerio
 grhl2bENSDARG00000061974Danio rerio
 GRHL2ENSGALG00000037687Gallus gallus
 GRHL2ENSG00000083307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grhl1 / Q921D9 / Grainyhead-like / Q9NZI5* / grainyhead like transcription factor 1*ENSMUSG0000002065658
Grhl3 / Q5FWH3 / Grainyhead-like / Q8TE85* / grainyhead like transcription factor 3*ENSMUSG0000003718845
Tfcp2 / Q9ERA0 / Mus musculus transcription factor CP2 (Tfcp2), transcript variant 3, mRNA. / Q12800* / transcription factor CP2*ENSMUSG0000000973320
Ubp1 / Q811S7 / upstream binding protein 1 / Q9NZI7*ENSMUSG0000000974120
Q3UNW5 / Tfcp2l1 / Transcription factor CP2-like protein 1 / Q9NZI6* / transcription factor CP2 like 1*ENSMUSG0000002638019


Protein motifs (from Interpro)
Interpro ID Name
 IPR007604  CP2 transcription factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0003382 epithelial cell morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030323 respiratory tube development IMP
 biological_processGO:0034329 cell junction assembly IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045617 negative regulation of keratinocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060324 face development IMP
 biological_processGO:0060463 lung lobe morphogenesis IMP
 biological_processGO:0060487 lung epithelial cell differentiation IMP
 biological_processGO:0060672 epithelial cell morphogenesis involved in placental branching IMP
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0090132 epithelium migration IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001161 intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0004687 split vertebrae "any vertebrae or vertebral section that is cleft into two parts " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2+,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2tm1.1Jane/Grhl2tm1.1Jane,Grhl3tm1Jane/Grhl3+
Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0012544 abnormal caudal neuropore morphology "any structural anomaly of the temporary opening at the extreme caudal end of the neural tube in early embryos; the posterior neuropore appears before the process of neural tube closure is complete" [MGI:anna]
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Allelic Composition: Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0012686 everted embryonic neuroepithelium "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [MGI:anna]
Show

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012707 incomplete caudal neuropore closure "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [MGI:anna]
Show

Allelic Composition: Tyrc-44H/Tyrc-44H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
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Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0030579 thoracoabdominoschisis "a congenital fissure of both the thoracic and abdominal walls" [https://www.ncbi.nlm.nih.gov/medgen/672583]
Show

Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: 129S1.B6-Grhl2m1Nisw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr