ENSG00000136327


Homo sapiens

Features
Gene ID: ENSG00000136327
  
Biological name :NKX2-8
  
Synonyms : NK2 homeobox 8 / NKX2-8 / O15522
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q13.3
Gene start: 36580579
Gene end: 36582607
  
Corresponding Affymetrix probe sets: 207451_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258829
NCBI entrez gene - 26257     See in Manteia.
OMIM - 603245
RefSeq - NM_014360
RefSeq Peptide - NP_055175
swissprot - O15522
Ensembl - ENSG00000136327
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX2-8ENSGALG00000028483Gallus gallus
 Nkx2-9ENSMUSG00000058669Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX2-2 / O95096 / NK2 homeobox 2ENSG0000012582044
NKX2-3 / Q8TAU0 / NK2 homeobox 3ENSG0000011991937
NKX2-5 / P52952 / NK2 homeobox 5ENSG0000018307236
NKX2-4 / Q9H2Z4 / NK2 homeobox 4ENSG0000012581636
NKX2-1 / P43699 / NK2 homeobox 1ENSG0000013635236
A6NCS4 / NKX2-6 / NK2 homeobox 6ENSG0000018005335
NKX3-2 / P78367 / NK3 homeobox 2ENSG0000010970528
HMX1 / Q9NP08 / H6 family homeobox 1ENSG0000021561225
NKX3-1 / Q99801 / NK3 homeobox 1ENSG0000016703423
HMX3 / A6NHT5 / H6 family homeobox 3ENSG0000018862023
HMX2 / A2RU54 / H6 family homeobox 2ENSG0000018881622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development NAS
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0030323 respiratory tube development IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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