ENSG00000125820


Homo sapiens

Features
Gene ID: ENSG00000125820
  
Biological name :NKX2-2
  
Synonyms : NK2 homeobox 2 / NKX2-2 / O95096
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p11.22
Gene start: 21511010
Gene end: 21514026
  
Corresponding Affymetrix probe sets: 206915_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366347
NCBI entrez gene - 4821     See in Manteia.
OMIM - 604612
RefSeq - NM_002509
RefSeq Peptide - NP_002500
swissprot - O95096
Ensembl - ENSG00000125820
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90481ENSDARG00000053298Danio rerio
 NKX2-2ENSGALG00000036869Gallus gallus
 Nkx2-2ENSMUSG00000027434Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX2-4 / Q9H2Z4 / NK2 homeobox 4ENSG0000012581639
NKX2-8 / O15522 / NK2 homeobox 8ENSG0000013632738
NKX2-3 / Q8TAU0 / NK2 homeobox 3ENSG0000011991938
NKX2-1 / P43699 / NK2 homeobox 1ENSG0000013635236
A6NCS4 / NKX2-6 / NK2 homeobox 6ENSG0000018005336
NKX2-5 / P52952 / NK2 homeobox 5ENSG0000018307232
NKX3-2 / P78367 / NK3 homeobox 2ENSG0000010970527
NKX3-1 / Q99801 / NK3 homeobox 1ENSG0000016703421
HMX1 / Q9NP08 / H6 family homeobox 1ENSG0000021561219
HMX3 / A6NHT5 / H6 family homeobox 3ENSG0000018862019
HMX2 / A2RU54 / H6 family homeobox 2ENSG0000018881618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003326 pancreatic A cell fate commitment IEA
 biological_processGO:0003327 type B pancreatic cell fate commitment IEA
 biological_processGO:0003329 pancreatic PP cell fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development TAS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IEA
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IEA
 biological_processGO:0021554 optic nerve development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060580 ventral spinal cord interneuron fate determination IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression in beta cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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