ENSGALG00000036869


Gallus gallus

Features
Gene ID: ENSGALG00000036869
  
Biological name :NKX2-2
  
Synonyms : NK2 homeobox 2 / NKX2-2
  
Possible biological names infered from orthology : O95096 / P42586
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 3523526
Gene end: 3524563
  
Corresponding Affymetrix probe sets: Gga.435.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054805
NCBI entrez gene - 428549     See in Manteia.
RefSeq - NM_001277718
RefSeq - XM_015283379
RefSeq Peptide - NP_001264647
swissprot - A0A1D5PPK4
Ensembl - ENSGALG00000036869
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90481ENSDARG00000053298Danio rerio
 NKX2-2ENSG00000125820Homo sapiens
 Nkx2-2ENSMUSG00000027434Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX2-8 / NK2 homeobox 8 / Nkx2-9* / O15522* / O70584* / Homeobox protein Nkx-2.8 *ENSGALG0000002848341
NKX2-1 / homeobox protein Nkx-2.1 ENSGALG0000003763236
NKX2-3 / NK2 homeobox 3 / P97334* / Q8TAU0* / Homeobox protein Nkx-2.3 *ENSGALG0000003093234
NKX2-5 / homeobox protein Nkx-2.5 ENSGALG0000000288632
NKX2-4 / NK2 homeobox 4 / Q9EQM3* / Q9H2Z4* / Homeobox protein Nkx-2.4 *ENSGALG0000003583531
NKX2-6 / homeobox protein Nkx-2.6 ENSGALG0000000036529
NKX3-2 / homeobox protein Nkx-3.2 / P78367* / P97503* / NK3 homeobox 2*ENSGALG0000003185925
HMX2 / H6 family homeobox 2 / A2RU54* / P43687* / Homeobox protein HMX2 *ENSGALG0000003087518
HMX1 / homeobox protein HMX1 ENSGALG0000004206218
HMX3 / homeobox protein HMX3 / A6NHT5* / P42581* / H6 family homeobox 3*ENSGALG0000002341518
SOHO-1 / sensory organ homeobox protein SOHo / HMX1* / O70218* / Q9NP08* / H6 family homeobox 1* / Homeobox protein HMX1 *ENSGALG0000001559915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003326 pancreatic A cell fate commitment IEA
 biological_processGO:0003327 type B pancreatic cell fate commitment IEA
 biological_processGO:0003329 pancreatic PP cell fate commitment IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IEA
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060580 ventral spinal cord interneuron fate determination IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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