ENSMUSG00000027434


Mus musculus

Features
Gene ID: ENSMUSG00000027434
  
Biological name :Nkx2-2
  
Synonyms : NK2 homeobox 2 / Nkx2-2 / P42586
  
Possible biological names infered from orthology : O95096
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G2
Gene start: 147177546
Gene end: 147194243
  
Corresponding Affymetrix probe sets: 10488366 (MoGene1.0st)   1421112_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069666
Ensembl peptide - ENSMUSP00000105596
NCBI entrez gene - 18088     See in Manteia.
MGI - MGI:97347
RefSeq - XM_011239349
RefSeq - NM_001077632
RefSeq - NM_010919
RefSeq - XM_006498898
RefSeq - XM_006498899
RefSeq - XM_006498900
RefSeq Peptide - NP_001071100
RefSeq Peptide - NP_035049
swissprot - Q8BRS9
swissprot - P42586
swissprot - Q3URZ4
Ensembl - ENSMUSG00000027434
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90481ENSDARG00000053298Danio rerio
 NKX2-2ENSGALG00000036869Gallus gallus
 NKX2-2ENSG00000125820Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*ENSMUSG0000005416038
Nkx2-3 / P97334 / Homeobox protein Nkx-2.3 / Q8TAU0* / NK2 homeobox 3*ENSMUSG0000004422037
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*ENSMUSG0000000149636
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*ENSMUSG0000005866934
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*ENSMUSG0000001557933
Nkx2-6 / P43688 / Homeobox protein Nkx-2.6 / A6NCS4* / NK2 homeobox 6*ENSMUSG0000004418630
Nkx3-2 / P97503 / Homeobox protein Nkx-3.2 / P78367* / NK3 homeobox 2*ENSMUSG0000004969127
Hmx1 / O70218 / Homeobox protein HMX1 / Q9NP08* / H6 family homeobox 1*ENSMUSG0000006743819
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*ENSMUSG0000004014819
Nkx3-1 / P97436 / NK3 homeobox 1 / Q99801*ENSMUSG0000002206119
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*ENSMUSG0000005010019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0003326 pancreatic A cell fate commitment IMP
 biological_processGO:0003327 type B pancreatic cell fate commitment IMP
 biological_processGO:0003329 pancreatic PP cell fate commitment IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IMP
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IDA
 biological_processGO:0021554 optic nerve development IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048708 astrocyte differentiation IMP
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060580 ventral spinal cord interneuron fate determination IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?,Tg(Hoxa2-cre)1Dym/?
Genetic Background: Not Specified

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Arxtm1Gldn/Arxtm1Gldn,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Nkx2-2tm3Suss/Nkx2-2tm3Suss
Genetic Background: involves: 129S6/SvEvTac

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-2tm3Suss/Nkx2-2tm3Suss
Genetic Background: involves: 129S6/SvEvTac

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1tm1.1Cbln/Foxn1tm1Tbo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx2-2tm3Suss/Nkx2-2tm3Suss
Genetic Background: involves: 129S6/SvEvTac

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Arxtm1Gldn/Arxtm1Gldn,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL

Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: Black Swiss * C57BL/6 * CBA/J * SJL

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Nkx2-2tm3Suss/Nkx2-2tm3Suss
Genetic Background: involves: 129S6/SvEvTac

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0009186 decreased PP cell number "reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0009190 increased pancreatic epsilon cell number "increase in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
Show

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr