ENSMUSG00000022061


Mus musculus

Features
Gene ID: ENSMUSG00000022061
  
Biological name :Nkx3-1
  
Synonyms : NK3 homeobox 1 / Nkx3-1 / P97436
  
Possible biological names infered from orthology : Q99801
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 69190638
Gene end: 69194662
  
Corresponding Affymetrix probe sets: 10416195 (MoGene1.0st)   1449998_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022646
NCBI entrez gene - 18095     See in Manteia.
MGI - MGI:97352
RefSeq - NM_010921
RefSeq Peptide - NP_035051
swissprot - P97436
swissprot - Q3UVH8
Ensembl - ENSMUSG00000022061
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx3-1ENSDARG00000078280Danio rerio
 NKX3-1ENSG00000167034Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx3-2 / P97503 / Homeobox protein Nkx-3.2 / P78367* / NK3 homeobox 2*ENSMUSG0000004969139
Nkx2-3 / P97334 / Homeobox protein Nkx-2.3 / Q8TAU0* / NK2 homeobox 3*ENSMUSG0000004422027
Hmx1 / O70218 / Homeobox protein HMX1 / Q9NP08* / H6 family homeobox 1*ENSMUSG0000006743827
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*ENSMUSG0000004014826
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*ENSMUSG0000001557925
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*ENSMUSG0000005416025
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*ENSMUSG0000000149624
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*ENSMUSG0000005010024
Nkx2-6 / P43688 / Homeobox protein Nkx-2.6 / A6NCS4* / NK2 homeobox 6*ENSMUSG0000004418623
Nkx2-2 / P42586 / NK2 homeobox 2 / O95096*ENSMUSG0000002743422
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*ENSMUSG0000005866920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001655 urogenital system development TAS
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0001756 somitogenesis IEP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007431 salivary gland development IMP
 biological_processGO:0007507 heart development IEP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0030850 prostate gland development TAS
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033574 response to testosterone IMP
 biological_processGO:0035260 internal genitalia morphogenesis TAS
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035907 dorsal aorta development IEP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060037 pharyngeal system development IEP
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IMP
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0071899 negative regulation of estrogen receptor binding IEA
 biological_processGO:2000836 positive regulation of androgen secretion IEA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004882 androgen receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0030284 estrogen receptor activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0097162 MADS box domain binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Mst1rtm1Sjd/Mst1r+
Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)

 MP:0000615 abnormal palatine gland morphology "malformed salivary gland of the hard palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64981]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000616 reduced ductal branching, palatine gland "fewer branches and distal tips of the vesicles of the palatine gland" [J:64981]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000617 increased number of salivary gland mucosal cells "greater than normal number of cells that form mucus in the salivary glands" [J:64981]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000618 small salivary gland "reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0000619 salivary gland epithelial hyperplasia "increased cell number in the epithelium of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0000620 narrow salivary ducts "reduced diameter of the tubular canals that carry saliva" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0000660 lateral prostate hypoplasia "reduced cell number in the lateral lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000661 small ventral prostate "reduced size of lateral lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000664 small coagulating gland "reduced size of the coagulating gland" [J:64981]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000665 decreased ductal branching, coagulating gland "fewer branches and distal tips of the vesicles of the coagulating gland" [J:64981]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000666 reduced number of prostate ducts "fewer than normal minute canals that pass the prostatic secretions to the urethra" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000671 bulbourethral gland hypoplasia "decreased cell number in the bulbourethral gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54465]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Klf6tm1Fjs/Klf6tm1Fjs,Nkx3-1tm3(cre)Mms/Nkx3-1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Hha/Nkx3-1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Hha/Nkx3-1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001169 abnormal bulbourethral gland morphology "malformed gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:54465, J:63764]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0001272 increased metastatic potential 
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Nkx3-1tm1Hha/Nkx3-1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
Genetic Background: involves: C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0003791 abnormal minor salivary gland morphology "any structural malformations of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005305 coagulating gland hyperplasia "increased number of normal cells in the anterior lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: involves: 129S1/Sv

Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009517 abnormal salivary gland duct morphology "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

 MP:0009734 abnormal prostate gland duct morphology "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Klf6tm1Fjs/Klf6tm1Fjs,Nkx3-1tm3(cre)Mms/Nkx3-1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009736 abnormal prostate gland branching morphogenesis "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Klf6tm1Fjs/Klf6tm1Fjs,Nkx3-1tm3(cre)Mms/Nkx3-1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011781 abnormal bulbourethral gland physiology "any functional anomaly of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, which produce a clear, salty, viscous secretion known as pre-ejaculate (aka as pre-ejaculatory fluid, preseminal fluid, or Cowper s fluid) upon sexual stimulation; this fluid is believed to lubricate the urethra for spermatozoa to pass through and neutralize traces of acidic urine in the urethra" [MGI:anna]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0013736 abnormal bulbourethral gland development "aberrant formation or incomplete differentiation of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; in mouse, bulbourethral glands are first identifiable at E17.5 and epithelial branching normally starts at postnatal day P1; during development, bulbourethral glands arise as epithelial outgrowths of the endodermal urogenital sinus invading the condensed mesenchyme flanking the primitive urethra; during subsequent development the epithelium branches extensively, filling the mesenchymal capsule and giving rise to the highly arborized ductal system of the mature organ" [MGI:Anna, PMID:12220125]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0013737 small bulbourethral gland "reduced size of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle" [MGI:Anna, PMID:19117991]
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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