Manteia

ENSMUSG00000049691

Mus musculus

Features

Gene ID:	ENSMUSG00000049691

Biological name :	Nkx3-2

Synonyms :	Homeobox protein Nkx-3.2 / Nkx3-2 / P97503

Possible biological names infered from orthology :	NK3 homeobox 2 / P78367

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	B3
Gene start:	41761483
Gene end:	41764501

Corresponding Affymetrix probe sets:	10529752 (MoGene1.0st) 1421464_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000051990 NCBI entrez gene - 12020 See in Manteia. MGI - MGI:108015 RefSeq - NM_007524 RefSeq Peptide - NP_031550 swissprot - P97503 Ensembl - ENSMUSG00000049691

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nkx3.2	ENSDARG00000037639	Danio rerio
NKX3-2	ENSGALG00000031859	Gallus gallus
NKX3-2	ENSG00000109705	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nkx3-1 / P97436 / NK3 homeobox 1 / Q99801*	ENSMUSG00000022061	28
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*	ENSMUSG00000040148	27
Nkx2-3 / P97334 / Homeobox protein Nkx-2.3 / Q8TAU0* / NK2 homeobox 3*	ENSMUSG00000044220	25
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*	ENSMUSG00000054160	25
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*	ENSMUSG00000001496	24
Hmx1 / O70218 / Homeobox protein HMX1 / Q9NP08* / H6 family homeobox 1*	ENSMUSG00000067438	24
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*	ENSMUSG00000015579	23
Nkx2-2 / P42586 / NK2 homeobox 2 / O95096*	ENSMUSG00000027434	23
Nkx2-6 / P43688 / Homeobox protein Nkx-2.6 / A6NCS4* / NK2 homeobox 6*	ENSMUSG00000044186	21
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*	ENSMUSG00000050100	21
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*	ENSMUSG00000058669	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001501	skeletal system development	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0031016	pancreas development	IMP
biological_process	GO:0032331	negative regulation of chondrocyte differentiation	IMP
biological_process	GO:0042474	middle ear morphogenesis	IMP
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0048513	animal organ development	IMP
biological_process	GO:0048536	spleen development	IMP
biological_process	GO:0048645	animal organ formation	IMP
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0048706	embryonic skeletal system development	IMP
biological_process	GO:0055123	digestive system development	IMP
biological_process	GO:0060576	intestinal epithelial cell development	IGI
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000030	abnormal tympanic ring morphology	"malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr,Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J
MP:0000071	axial skeleton hypoplasia	"reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000078	abnormal supraoccipital bone morphology	"malformed upper part of the occipital bone" [J:61509]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000079	abnormal basioccipital bone morphology	"malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000080	abnormal exoccipital bone morphology	"malformed lateral part of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000106	abnormal basisphenoid bone morphology	"malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2⁺ Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000141	abnormal vertebral body morphology	"malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atm^tm1Led/Atm^tm1Led Genetic Background: involves: 129S6/SvEvTac * Black Swiss
MP:0000164	abnormal cartilage development	"anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000462	abnormal digestive system morphology	"anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Spi1^tm1Sing/Spi1⁺,Spib^tm1Mcs/Spib^tm1Mcs Genetic Background: involves: 129S/SvEv * 129X1/SvJ Allelic Composition: Gli3^tm1Alj/Gli3^tm1Alj,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺,Smo^tm2Amc/Smo^tm2Amc Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
MP:0000470	abnormal stomach morphology	"malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0000471	abnormal stomach epithelium morphology	"malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0000473	abnormal stomach glandular epithelium morphology	"malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000588	thick tail	"a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0001046	abnormal enteric neuron morphology	"malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40 Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0001255	decreased body height	"decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0001268	barrel chest	"distended circumference of the thoracic and abdominal areas" [J:55583]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atm^tm1Led/Atm^tm1Led Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s-162H/Ednrb^s-162H Genetic Background: involves: C3H/HeH Allelic Composition: Nkx3-2^{tm4.1(cre)Tlu}/Nkx3-2^{tm4.1(cre)Tlu} Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002691	small stomach	"reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003048	abnormal cervical vertebrae morphology	"malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003119	abnormal digestive system development	"dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0003283	abnormal digestive organ placement	"different location or arrangement of any of the alimentary tract organs" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003449	abnormal intestinal goblet cells	"malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]	Show Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0003934	abnormal pancreas development	"anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004139	abnormal parietal cell morphology	"malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004443	absent supraoccipital bone	"absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004445	small exoccipital bone	"reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004447	small basioccipital bone	"reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004461	basisphenoid bone hypoplasia	"underdevelopment or reduced size, usually due to reduced cell number, in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004462	small basisphenoid bone	"reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004607	abnormal cervical atlas morphology	"any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004608	abnormal cervical axis morphology	"any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004610	small vertebrae	"reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004626	vertebral compression	"appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004652	small caudal vertebrae	"reduced size of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004659	abnormal odontoid process	"any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A02.835.232.834.151.383.668]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004667	vertebral body hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004668	absent vertebral body	"absence of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004683	absent intervertebral disk	"absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map1b^tm1Rak/Map1b⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004704	short vertebral column	"decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004711	persistence of notochord tissue	"failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004733	abnormal thoracic cavity	"any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005226	abnormal vertebral arch development	"anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005227	abnormal vertebral body development	"anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Map1b^tm1Rak/Map1b⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006029	abnormal sclerotome	"malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0008381	absent gonial bone	"absence of the investing bone that normally lies on the surface of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008382	gonial bone hypoplasia	"underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008385	absent basisphenoid bone	"absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map1b^tm1Rak/Map1b⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008802	abnormal intestinal smooth muscle morphology	"any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0008883	abnormal enterocyte proliferation	"anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0009609	absent basioccipital bone	"absence of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Map1b^tm1Rak/Map1b⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009917	abnormal hyoid bone body morphology	"any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010155	abnormal intestine physiology	"any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0010158	abnormal intestine development	"abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0010729	absent arcus anterior	"absence of the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0010731	absent ventral tubercle of atlas	"absence of the conical ventral projection on the arch of the atlas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0010780	abnormal stomach smooth muscle circular layer morphology	"any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0010785	abnormal stomach pyloric region morphology	"any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0010802	abnormal intestinal enteroendocrine cell morphology	"any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh,Foxc2^tm1Blh/Foxc2^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Nkx3-2^tm1Tlu/Nkx3-2^tm1Tlu Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) Allelic Composition: Smo^tm2Amc/Smo^tm2Amc,Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh,Nkx3-1^tm1Hha/Nkx3-1^tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0013575	abnormal forestomach-glandular stomach junction morphology	"any structural anomaly of the distinct low fold of tissue that separates the non-glandular area of the stomach (forestomach) from the glandular stomach; the limiting ridge extends circumferentially from the large curvature of the stomach to the small curvature, just below the esophagus; at the esophagus, the course of the limiting ridge bends into a U-shape and almost surrounds the esophageal opening" [http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CCUQFjAB&url=http%3A%2F%2Fjournals.usamvcluj.ro%2Findex.php%2Fveterinary%2Farticle%2Fdownload%2F5889%2F5384&ei=nQ61VJvFEMuQyASZpYGgCw&usg=AFQjCNHtPvbkRJR7v3Jh2Ht2z-s9qVBLGA&bvm=bv.83339334,d.aWw&cad=rja, MGI:anna]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0013576	small forestomach	"reduced size of the distinct rodent non-glandular region of the stomach which is demarcated from the glandular stomach by the limiting ridge (margo plicatus)" [MGI:Anna]	Show Allelic Composition: Col4a1^deltaex40/Col4a1⁺ Genetic Background: B6.129S-Col4a1^deltaex40
MP:0030027	basioccipital bone hypoplasia	"underdevelopment or reduced size, usually due to reduced cell number, of the basilar process of the occipital bone in the base of the cranium that frequently forms a direct part of the occipital in the adult, but is usually distinct in the young" [MGI:anna]	Show Allelic Composition: Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nkx3-2^tm1Tno/Nkx3-2^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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