ENSMUSG00000044186


Mus musculus

Features
Gene ID: ENSMUSG00000044186
  
Biological name :Nkx2-6
  
Synonyms : Homeobox protein Nkx-2.6 / Nkx2-6 / P43688
  
Possible biological names infered from orthology : A6NCS4 / NK2 homeobox 6
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 69171802
Gene end: 69175518
  
Corresponding Affymetrix probe sets: 10416189 (MoGene1.0st)   1443817_x_at (Mouse Genome 430 2.0 Array)   1452018_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049898
NCBI entrez gene - 18092     See in Manteia.
MGI - MGI:97351
RefSeq - NM_010920
RefSeq - XM_006518679
RefSeq Peptide - NP_035050
swissprot - P43688
Ensembl - ENSMUSG00000044186
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx2.3ENSDARG00000039095Danio rerio
 nkx2.5ENSDARG00000018004Danio rerio
 nkx2.7ENSDARG00000021232Danio rerio
 A6NCS4ENSG00000180053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx2-3 / P97334 / Homeobox protein Nkx-2.3 / Q8TAU0* / NK2 homeobox 3*ENSMUSG0000004422044
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*ENSMUSG0000001557938
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*ENSMUSG0000005416034
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*ENSMUSG0000000149632
Nkx2-2 / P42586 / NK2 homeobox 2 / O95096*ENSMUSG0000002743429
Nkx3-2 / P97503 / Homeobox protein Nkx-3.2 / P78367* / NK3 homeobox 2*ENSMUSG0000004969124
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*ENSMUSG0000005866924
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*ENSMUSG0000004014821
Hmx1 / O70218 / Homeobox protein HMX1 / Q9NP08* / H6 family homeobox 1*ENSMUSG0000006743820
Nkx3-1 / P97436 / NK3 homeobox 1 / Q99801*ENSMUSG0000002206119
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*ENSMUSG0000005010018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0021854 hypothalamus development IEP
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0035050 embryonic heart tube development IEP
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043586 tongue development IEP
 biological_processGO:0048565 digestive tract development IEP
 biological_processGO:0055014 atrial cardiac muscle cell development IEP
 biological_processGO:0055015 ventricular cardiac muscle cell development IEP
 biological_processGO:0060037 pharyngeal system development IGI
 biological_processGO:0060039 pericardium development IEP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0002234 abnormal pharynx morphology "structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0004555 pharynx hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells,of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0006031 abnormal branchial pouch morphology "malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr