MP:0000026 | abnormal inner ear morphology | "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0000035 | abnormal membranous labyrinth | "malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0000036 | absent semicircular canals | "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0000037 | abnormal lateral semicircular canal | "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0000041 | absent endolymphatic duct | "missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0000743 | muscle spasms | "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: KitW-f/KitW-f Genetic Background: involves: C3H/HePas
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MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: KitW-f/KitW-f Genetic Background: involves: C3H/HePas
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MP:0001728 | failure of implantation | "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772] |
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0001752 | abnormal hypothalamus secretion | "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0002428 | abnormal semicircular canal | "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo Genetic Background: involves: 129S4/SvJae
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MP:0002858 | abnormal posterior semicircular canal | "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0003069 | abnormal superior semicircular canal | "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0003161 | absent lateral semicircular canal | |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0003162 | reduced size of lateral semicircular canal | |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0003163 | absent posterior semicircular canal | |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0003164 | reduced size of posterior semicircular canal | |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0003166 | reduced size of superior semicircular canal | |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0003845 | abnormal decidualization | "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0004249 | abnormal crista ampullaris morphology | "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0004314 | absent vestibule | "absence of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba Genetic Background: involves: C57BL/6 * CBA
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MP:0004328 | decreased vestibular hair cell number | "decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0004329 | saccular degeneration | "degeneration or loss of the smaller of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0004331 | saccular macula degeneration | "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0004332 | utricular degeneration | "degeneration or loss of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0004333 | abnormal utricular macula morphology | "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0004334 | utricular macular degeneration | "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0004425 | abnormal otolith organ | "any structural abnormality in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0004427 | abnormal vestibular labyrinth | "any structural abnormality in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0005120 | decreased circulating growth hormone level | "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0005191 | head tilt | "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hmx2tm2Tlu/Hmx2tm2Tlu,Hmx3tm4(Hmx)Tlu/Hmx3tm4(Hmx)Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0005361 | small pituitary gland | "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0006011 | abnormal endolymphatic duct morphology | "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0006089 | abnormal saccule morphology | "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0006090 | abnormal utricle morphology | "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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MP:0008321 | small adenohypophysis | "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Hmx3/Hmx2tm3Tlu/Hmx3/Hmx2tm3Tlu Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6J)
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Hmx3tm1Tlu/Hmx3tm1Tlu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hmx3tm2Tlu/Hmx3tm2Tlu Genetic Background: involves: 129 * C57BL/6J
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