MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Hspb7tm1.1Chen/Hspb7tm1.1Chen,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5tm2.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5tm2.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph,Tbx20tm1.1Rph/Tbx20tm1.1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0000277 | abnormal heart shape | "malformation of the form or the patterning of the heart" [J:18048] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0000279 | ventricular hypoplasia | "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11 Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0000282 | abnormal atrial septum morphology | "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Vangl2Lp/Vangl2Lp Genetic Background: involves: LPT/LeJ
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB/N) or (involves: 129S1/Sv * C57BL/6 * QS)
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Nsd2tm1Ykan/Nsd2+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
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MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000292 | distended pericardial sacs | "stretched outer parietal layer of the pericardium" [J:25248] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0000293 | absent myocardial trabeculae | "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0000295 | poorly developed ventricular trabeculae | "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0000296 | absent ventricular trabeculae | "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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MP:0000298 | absent endocardial cushion | "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000301 | reduced size of endocardial cushions | "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973] |
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Allelic Composition: Agttm1Ii/Agt+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6J
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MP:0000484 | abnormal pulmonary artery morphology | "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Nkx2-5tm2(cre)Rph/Nkx2-5+,Pbx1tm1.1Koss/Pbx1tm1.1Koss Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
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MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Nkx2-5tm2(cre)Rph/Nkx2-5+,Pbx1tm1.1Koss/Pbx1tm1.1Koss Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
Allelic Composition: Nkx2-5tm2(cre)Rph/Nkx2-5tm4Rph Genetic Background: involves: 129S1/Sv
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd
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MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0000729 | abnormal myogenesis | "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Asxl1tm1.1Mjxu/Asxl1+ Genetic Background: involves: 129 * C57BL/6
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N
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MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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MP:0001633 | poor circulation | "insufficient movement of blood throughout the body" [MGI:cls, J:45302] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001689 | incomplete somite formation | "arrest of differentiation or patterning of the somites" [J:62882] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Daam1Gt(RRT390)Byg/Daam1Gt(RRT390)Byg,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
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MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0001786 | skin edema | "accumulation of an excessive amount of fluid in the skin" [J:65039] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6
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MP:0001855 | atrial thrombosis | "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kcnh3tm1.1(KOMP)Vlcg/Kcnh3+ Genetic Background: C57BL/6N-Kcnh3tm1.1(KOMP)Vlcg/J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Zic3tm2.1Jwb/Y Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6J
Allelic Composition: Zic3tm1.1Smwa/Y,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Nkx2-5tm1.1Pash/Nkx2-5tm1.1Pash Genetic Background: B6.129-Nkx2-5tm1.1Pash
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,Nkx2-5tm1(cre)Rjs/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Nkx2-5tm1.1Wtp/Nkx2-5tm1.1Wtp Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster
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MP:0002189 | abnormal myocardial trabeculae morphology | "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5a+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0002190 | disorganized myocardium | "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nrp2tm1.2Mom/Nrp2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ
Allelic Composition: Smotm2Amc/Smotm2.1Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
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MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002234 | abnormal pharynx morphology | "structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Smotm2Amc/Smotm2.1Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: GckGls006/Gck+ Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Agttm1Ii/Agt+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0002746 | abnormal semilunar valve morphology | "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002747 | abnormal aortic valve morphology | "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Vangl2Lp/Vangl2Lp Genetic Background: involves: LPT/LeJ
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MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Oclntm1Sts/Oclntm1Sts Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
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MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
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MP:0002884 | abnormal branchial arches | "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0002950 | abnormal neural crest cell migration | "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Smotm2Amc/Smotm2.1Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
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MP:0002953 | thick ventricular wall | "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0003105 | abnormal heart atrium morphology | "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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MP:0003137 | abnormal impulse conducting system conduction | "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm3Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: C57BL/6
Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0003157 | impaired muscle relaxation | "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510] |
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Allelic Composition: Foxc1ch/Foxc1+ Genetic Background: involves: CBA * STOCK Tyrc f
Allelic Composition: Nkx2-5tm6Rph/Nkx2-5+,Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm Genetic Background: involves: 129S1/Sv * FVB/N
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MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0003223 | decreased cardiomyocyte apoptosis | "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0003228 | abnormal sinus venosus | "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0003393 | decreased cardiac output | "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0003547 | abnormal pulmonary pressure | "altered tension of the blood within the pulmonary arteries" [J:54986, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0003567 | abnormal cardiomyocyte proliferation | "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+,Tg(CAG-EGFP)D4Nagy/0,Tg(Hmgcr-lacZ)H253Sest/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
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MP:0003649 | reduced right ventricle | |
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Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0003822 | decreased left ventricle systolic pressure | "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0003872 | absent right ventricle | "missing the lower right chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Tg(Mef2c-cre)#Blk/0 Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * C57BL/6
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MP:0003873 | branchial arch hypoplasia | "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0003896 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
Allelic Composition: Nkx2-5tm6Rph/Nkx2-5+,Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/0 Genetic Background: involves: 129S1/Sv * FVB/N
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MP:0003897 | abnormal ST interval | "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0003898 | abnormal QRS complex | "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0003901 | abnormal PQ interval | "anomaly in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0003916 | decreased left ventricle weight | "less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0004009 | abnormal diastolic filling velocity | "anomaly in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:Rat Genome Database submission] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0004056 | abnormal myocardial compact layer morphology | "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004057 | thin myocardial compact layer | "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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MP:0004062 | dilated right atrium | "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0004071 | prolonged P wave | "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004090 | abnormal sarcomere morphology | "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004092 | absent Z lines | "missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004093 | diffuse Z lines | "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004114 | abnormal atrioventricular node morphology | "structural anomaly in the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0004117 | abnormal atrioventricular bundle morphology | "structural anomaly in the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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MP:0004123 | abnormal impulse conducting system morphology | "structural anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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MP:0004124 | abnormal Purkinje fiber morphology | "structural anomaly in the cardiac muscle fibers composing the terminal portion of the heart conduction system located in the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004146 | absent M lines | "missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0004225 | patent foramen ovale | "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB/N) or (involves: 129S1/Sv * C57BL/6 * QS)
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0004251 | failure of looping morphogenesis | "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5tm2.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0004484 | altered response of heart to induced stress | "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0004555 | pharynx hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells,of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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MP:0004565 | small myocardial fiber | "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0004759 | decreased mitotic index | "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0004787 | abnormal dorsal aorta morphology | "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0004937 | dilated heart | "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
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MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5tm4Rph Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S/SvEv
Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6
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MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S/SvEv
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MP:0005439 | decreased glycogen level | "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hccstm1Tcc/Hccstm1Tcc,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl Genetic Background: B6.129S7-Cd47tm1Fpl
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MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
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MP:0006031 | abnormal branchial pouch morphology | "malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6J
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MP:0006107 | abnormal atrioventricular canal morphology | "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0006113 | abnormal heart septum morphology | "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Sod2tm1Cje/Sod2+ Genetic Background: involves: C57BL/6J * DBA/2J
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MP:0006117 | aortic valve stenosis | "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Vangl2Lp/Vangl2Lp Genetic Background: involves: LPT/LeJ
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MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Smotm2Amc/Smotm2.1Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Tg(Mef2c-cre)#Blk/0 Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * C57BL/6
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MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0006141 | abnormal atrioventricular node conduction | "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm6Rph/Nkx2-5+,Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm Genetic Background: involves: 129S1/Sv * FVB/N
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MP:0006142 | abnormal sinoatrial node conduction | "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0006207 | embryonic lethality during organogenesis | "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6+ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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MP:0006267 | abnormal intercalated disc morphology | "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0008727 | enlarged right atrium | "increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0008788 | abnormal fetal cardiomyocyte morphology | "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040] |
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+,Tg(CAG-EGFP)D4Nagy/0,Tg(Hmgcr-lacZ)H253Sest/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0008825 | abnormal cardiac epithelial to mesenchymal transition | "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0009382 | abnormal cardiac jelly morphology | "any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0009844 | abnormal neural crest cell apoptosis | "change in the timing or the number of neural crest cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Shhtm1Chg/Shhtm2Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Smotm2Amc/Smotm2.1Amc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
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MP:0009845 | abnormal neural crest cell morphology | "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0009861 | abnormal pyloric sphincter morphology | "any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6J
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MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Nsd2tm1Ykan/Nsd2+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010412 | atrioventricular septal defect | "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com] |
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0010416 | interventricular septum membranous part aneurysm | "a a saclike thinning, stretching and widening of the ventricular membranous septum resulting from weakening of the membraneous septum wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Nsd2tm1Ykan/Nsd2+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0010422 | heart right ventricle hypoplasia | "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0010432 | common ventricle | "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0010450 | atrial septal aneurysm | "a saclike thinning, stretching and widening of the heart atrial septum resulting from weakening of the septum wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB/N) or (involves: 129S1/Sv * C57BL/6 * QS)
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MP:0010455 | aortopulmonary window | "a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010464 | abnormal aortic arch and aortic arch branch attachment | "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010484 | bicuspid aortic valve | "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+ Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J)
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MP:0010498 | abnormal interventricular septum muscular part morphology | "any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010508 | abnormal heart electrocardiography waveform feature | "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0010520 | sinoatrial block | "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010533 | atrioventricular node hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus" [MESH:A07.541.409.147] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0010551 | abnormal coronary vessel morphology | "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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MP:0010556 | thin ventricle myocardium compact layer | "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010557 | dilated pulmonary artery | "the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010559 | heart block | "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010571 | shortened ST segment | "reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0010585 | abnormal conotruncal ridge morphology | "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Tmj/Isl1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0010587 | conotruncal ridge hypoplasia | "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0010593 | thick aortic valve cusps | "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J
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MP:0010614 | abnormal mitral valve cusp morphology | "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0010625 | absent tricuspid valve cusps | "absence of the three fibrous triangular components and associated flaps of the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0010626 | thick tricuspid valve cusps | |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010630 | abnormal cardiac muscle tissue morphology | "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010636 | bundle branch block | "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0010662 | abnormal intersomitic artery morphology | "any structural anomaly of the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0010724 | thick interventricular septum | "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0010754 | abnormal heart left ventricle pressure | "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0010759 | decreased right ventricle systolic pressure | "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0010780 | abnormal stomach smooth muscle circular layer morphology | "any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6J
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MP:0010805 | abnormal stomach smooth muscle outer longitudinal layer morphology | "any structural anomaly of the most superficial layer of the muscularis; it has two sections, a longitudinal layer that is common with the esophagus and ends in the corpus, and a longitudinal layer that originates in the corpus and spreads into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: C57BL/6J
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MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/10
Allelic Composition: Nkx2-5tm2Siz/Nkx2-5tm2Siz Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Siz/Nkx2-5tm1Siz,Nkx2-6tm1Siz/Nkx2-6tm1Siz Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S/SvEv
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Tg(Mef2c-cre)#Blk/0 Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5tm2.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
Allelic Composition: Hspb7tm1.1Chen/Hspb7tm1.1Chen,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Zfpm2tm1Sho/Zfpm2tm2Sho,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hccstm1Tcc/Hccstm1Tcc,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nkx2-5tm4Rph/Nkx2-5+,Tbx20tm1.1Rph/Tbx20+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0011205 | excessive folding of visceral yolk sac | "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0011262 | abnormal branchial arch mesenchyme morphology | "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
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MP:0011263 | abnormal spleen mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
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MP:0011388 | absent heart | "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
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MP:0011390 | abnormal fetal cardiomyocyte physiology | "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0011394 | increased fetal cardiomyocyte proliferation | "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Foxp1tm2.1Eem/Foxp1tm2.1Eem,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0011395 | decreased fetal cardiomyocyte proliferation | "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
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MP:0011952 | decreased cardiac stroke volume | "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith] |
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
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MP:0011953 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly] |
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Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0012179 | abnormal splanchnic mesoderm morphology | "any structural abnormality of the inner layer of lateral plate mesoderm, located above (dorsally) the endoderm, which forms the circulatory system and future gut wall" [MGI:anna] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm2Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129 * 129S7/SvEvBrd
Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
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MP:0012270 | cardiac edema | "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna] |
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0012492 | branchial arch artery hypoplasia | "underdevelopment or reduced size of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna] |
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Allelic Composition: Ngftm1Gne/Ngf+ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0012515 | abnormal heart apex morphology | "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna] |
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Nkx2-5tm2.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5+ Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
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MP:0014044 | absent cardiac outflow tract | "absence of or complete failure to form the common arterial trunk that normally forms the aorta and pulmonary artery and the ventricular outflow regions" [MGI:anna] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
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MP:0020409 | abnormal cardiac thrombosis | "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0030340 | absent fourth pharyngeal arch artery | "failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0030341 | fourth pharyngeal arch artery hypoplasia | "underdevelopment or reduced size of the fourth pharyngeal arch artery, usually due to a reduced number of cells" [MGI:anna] |
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0030564 | thick myocardium compact layer | "increased thickness of the outer, dense layer of the myocardium" [MGI:anna, PMID:26526197] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5a+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0030566 | abnormal A band morphology | "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0030567 | abnormal I band morphology | "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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MP:0030568 | abnormal H zone morphology | "any structural anomaly of the relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; it consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments; within the H zone is a thin dark M line, the attachment site for the thick filaments in the center of the sarcomere" [GO:0031673, https://en.wikipedia.org/wiki/Sarcomere] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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