ENSDARG00000018004


Danio rerio

Features
Gene ID: ENSDARG00000018004
  
Biological name :nkx2.5
  
Synonyms : NK2 homeobox 5 / nkx2.5
  
Possible biological names infered from orthology : A6NCS4 / Homeobox protein Nkx-2.3 / Homeobox protein Nkx-2.5 / Homeobox protein Nkx-2.6 / NK2 homeobox 3 / NK2 homeobox 6 / NKX2-3 / NKX2-6 / P42582 / P43688 / P52952 / P97334 / Q8TAU0
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 24241241
Gene end: 24244034
  
Corresponding Affymetrix probe sets: Dr.271.1.S1_at (Zebrafish Array)   NM_131421_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000016308
NCBI entrez gene - 30696     See in Manteia.
RefSeq - NM_131421
RefSeq Peptide - NP_571496
swissprot - F1RCL3
ZFIN ID - ZDB-GENE-980526-321
Ensembl - ENSDARG00000018004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX2-5ENSGALG00000002886Gallus gallus
 A6NCS4ENSG00000180053Homo sapiens
 NKX2-3ENSG00000119919Homo sapiens
 NKX2-5ENSG00000183072Homo sapiens
 Nkx2-3ENSMUSG00000044220Mus musculus
 Nkx2-5ENSMUSG00000015579Mus musculus
 Nkx2-6ENSMUSG00000044186Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nkx2.3 / NK2 homeobox 3 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-5* / NKX2-6* / NK2 homeobox 5* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000003909542
nkx2.7 / NK2 transcription factor related 7 / Q8TAU0* / NKX2-6* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-5* / NK2 homeobox 3* / NK2 homeobox 5* / NK2 homeobox 6* /...ENSDARG0000002123238
nkx2.1 / NK2 homeobox 1 / Q9H2Z4* / P43699* / P50220* / Q9EQM3* / NKX2-4* / NK2 homeobox 4* / Homeobox protein Nkx-2.1 * / Homeobox protein Nkx-2.4 *ENSDARG0000001983530
nkx2.4b / NK2 homeobox 4bENSDARG0000010410729
nkx2.4a / NK2 homeobox 4aENSDARG0000007510729
Q90481 / nkx2.2a / NK2 homeobox 2a / NKX2-2* / O95096* / NK2 homeobox 2*ENSDARG0000005329825
nkx2.2b / NK2 homeobox 2bENSDARG0000010154924
nkx3.2 / NK3 homeobox 2 / P78367*ENSDARG0000003763922
nkx3.3 / NK3 homeobox 3ENSDARG0000006932721
hmx3a / H6 family homeobox 3a / HMX3* / P42581* / A6NHT5* / H6 family homeobox 3* / Homeobox protein HMX3 *ENSDARG0000007095519
nkx3-1 / NK3 homeobox 1 / P97436* / Q99801*ENSDARG0000007828017
hmx2 / H6 family homeobox 2 / A2RU54* / P43687* / Homeobox protein HMX2 *ENSDARG0000007095416
hmx1 / H6 family homeobox 1 / O70218* / Q9NP08* / Homeobox protein HMX1 *ENSDARG0000009565116
hmx3b / H6 family homeobox 3bENSDARG0000009671616
hmx4 / H6 family homeobox 4ENSDARG0000000794116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003205 cardiac chamber development IMP
 biological_processGO:0003231 cardiac ventricle development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0060038 cardiac muscle cell proliferation IGI
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060840 artery development IGI
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:1901210 regulation of cardiac chamber formation IMP
 biological_processGO:1903779 regulation of cardiac conduction IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle dilated , abnormal
cardiac ventricle decreased size , abnormal
cardiac ventricle increased length , abnormal
cardiac ventricle increased width , abnormal
cardiac ventricle morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart functionality , ameliorated
heart morphology , abnormal
heart edematous , abnormal
heart decreased functionality , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
atrium shape , abnormal
atrium morphology , abnormal
atrium increased size , abnormal
Show

 ZFA:0000673 hypobranchial artery hypobranchial artery absent , abnormal
hypobranchial artery detached from lateral dorsal aorta , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism decreased life span , abnormal
whole organism dead , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage curved ventral , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch increased distribution , abnormal
pharyngeal arch decreased distribution , abnormal
pharyngeal arch ventral region decreased distribution , abnormal
Show

 ZFA:0001319 myocardium myocardium myofibril disorganized , abnormal
Show

 ZFA:0001374 atrial myocardium atrial myocardium cardiac muscle cell increased amount , abnormal
atrial myocardium increased width , abnormal
atrial myocardium distended , abnormal
atrial myocardium dilated , abnormal
atrial myocardium increased size , abnormal
atrial myocardium bulbous , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage malformed , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage hypoplastic , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage hypoplastic , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage decreased size , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage hypoplastic , abnormal
Show

 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 decreased distribution , abnormal
Show

 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 decreased distribution , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 absent , abnormal
pharyngeal arch 2 decreased distribution , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 absent , abnormal
pharyngeal arch 1 decreased distribution , abnormal
Show

 ZFA:0001655 pericardial cavity pericardial cavity edematous , abnormal
Show

 ZFA:0005003 pharyngeal vasculature pharyngeal vasculature malformed , abnormal
pharyngeal vasculature vasculogenesis decreased process quality , abnormal
pharyngeal vasculature pharyngeal arch artery morphogenesis decreased process quality , abnormal
pharyngeal vasculature has fewer parts of type blood vessel endothelial cell , abnormal
pharyngeal vasculature angioblast cell differentiation decreased process quality , abnormal
pharyngeal vasculature blood vessel endothelial cell differentiation decreased occurrence , abnormal
pharyngeal vasculature endothelial cell migration process quality , abnormal
Show

 ZFA:0005007 aortic arch 3 aortic arch 3 decreased amount , abnormal
aortic arch 3 absent , abnormal
Show

 ZFA:0005008 aortic arch 4 aortic arch 4 absent , abnormal
aortic arch 4 blood vessel lumenization decreased occurrence , abnormal
Show

 ZFA:0005009 aortic arch 5 aortic arch 5 blood vessel lumenization decreased occurrence , abnormal
aortic arch 5 absent , abnormal
aortic arch 5 blood vessel lumenization arrested , abnormal
Show

 ZFA:0005016 aortic arch 6 aortic arch 6 blood vessel lumenization decreased occurrence , abnormal
aortic arch 6 absent , abnormal
aortic arch 6 blood vessel lumenization arrested , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium cardiac muscle cell decreased amount , abnormal
ventricular myocardium decreased size , abnormal
ventricular myocardium shortened , abnormal
ventricular myocardium decreased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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