ENSDARG00000095651


Danio rerio

Features
Gene ID: ENSDARG00000095651
  
Biological name :hmx1
  
Synonyms : H6 family homeobox 1 / hmx1
  
Possible biological names infered from orthology : Homeobox protein HMX1 / O70218 / Q9NP08
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 40912613
Gene end: 40914752
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000102248
swissprot - B2KTE5
ZFIN ID - ZDB-GENE-080204-54
Ensembl - ENSDARG00000095651
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMX1ENSGALG00000042062Gallus gallus
 HMX1ENSG00000215612Homo sapiens
 Hmx1ENSMUSG00000067438Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hmx3a / H6 family homeobox 3a / HMX3* / P42581* / A6NHT5* / H6 family homeobox 3* / Homeobox protein HMX3 *ENSDARG0000007095543
hmx3b / H6 family homeobox 3bENSDARG0000009671634
hmx2 / H6 family homeobox 2 / A2RU54* / P43687* / Homeobox protein HMX2 *ENSDARG0000007095430
hmx4 / H6 family homeobox 4ENSDARG0000000794126
nkx3.2 / NK3 homeobox 2 / P78367*ENSDARG0000003763923
nkx3.3 / NK3 homeobox 3ENSDARG0000006932720
nkx2.3 / NK2 homeobox 3 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-5* / NKX2-6* / NK2 homeobox 5* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000003909519
nkx3-1 / NK3 homeobox 1 / P97436* / Q99801*ENSDARG0000007828018
nkx2.4a / NK2 homeobox 4aENSDARG0000007510718
nkx2.7 / NK2 transcription factor related 7 / Q8TAU0* / NKX2-6* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-5* / NK2 homeobox 3* / NK2 homeobox 5* / NK2 homeobox 6* /...ENSDARG0000002123218
nkx2.5 / NK2 homeobox 5 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-6* / NK2 homeobox 3* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000001800417
nkx2.1 / NK2 homeobox 1 / Q9H2Z4* / P43699* / P50220* / Q9EQM3* / NKX2-4* / NK2 homeobox 4* / Homeobox protein Nkx-2.1 * / Homeobox protein Nkx-2.4 *ENSDARG0000001983517
nkx2.2b / NK2 homeobox 2bENSDARG0000010154917
nkx2.4b / NK2 homeobox 4bENSDARG0000010410717
Q90481 / nkx2.2a / NK2 homeobox 2a / NKX2-2* / O95096* / NK2 homeobox 2*ENSDARG0000005329816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic process increased occurrence , abnormal
Show

 ZFA:0000035 lens lens apoptotic process increased occurrence , abnormal
lens opaque , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer absent , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell proliferation increased occurrence , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium increased thickness , abnormal
Show

 ZFA:0000152 retina retina apoptotic process increased occurrence , abnormal
retina cell proliferation increased occurrence , abnormal
Show

 ZFA:0001202 optic cup optic cup apoptotic process increased occurrence , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer cell proliferation increased occurrence , abnormal
Show

 ZFA:0001679 solid lens vesicle solid lens vesicle apoptotic process decreased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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