ENSDARG00000053298


Danio rerio

Features
Gene ID: ENSDARG00000053298
  
Biological name :nkx2.2a
  
Synonyms : NK2 homeobox 2a / nkx2.2a / Q90481
  
Possible biological names infered from orthology : NK2 homeobox 2 / NKX2-2 / O95096 / P42586
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 42208623
Gene end: 42218652
  
Corresponding Affymetrix probe sets: Dr.31.1.S1_at (Zebrafish Array)   NM_131422_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000153588
Ensembl peptide - ENSDARP00000075838
Ensembl peptide - ENSDARP00000117693
Ensembl peptide - ENSDARP00000154455
Ensembl peptide - ENSDARP00000154648
NCBI entrez gene - 30697     See in Manteia.
RefSeq - NM_131422
RefSeq Peptide - NP_001295569
RefSeq Peptide - NP_571497
swissprot - F1QNE4
swissprot - Q1RM24
swissprot - Q90481
ZFIN ID - ZDB-GENE-980526-403
Ensembl - ENSDARG00000053298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX2-2ENSGALG00000036869Gallus gallus
 NKX2-2ENSG00000125820Homo sapiens
 Nkx2-2ENSMUSG00000027434Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nkx2.2b / NK2 homeobox 2bENSDARG0000010154947
nkx2.1 / NK2 homeobox 1 / Q9H2Z4* / P43699* / P50220* / Q9EQM3* / NKX2-4* / NK2 homeobox 4* / Homeobox protein Nkx-2.1 * / Homeobox protein Nkx-2.4 *ENSDARG0000001983537
nkx2.4a / NK2 homeobox 4aENSDARG0000007510737
nkx2.4b / NK2 homeobox 4bENSDARG0000010410735
nkx2.3 / NK2 homeobox 3 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-5* / NKX2-6* / NK2 homeobox 5* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000003909535
nkx2.7 / NK2 transcription factor related 7 / Q8TAU0* / NKX2-6* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-5* / NK2 homeobox 3* / NK2 homeobox 5* / NK2 homeobox 6* /...ENSDARG0000002123234
nkx2.5 / NK2 homeobox 5 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-6* / NK2 homeobox 3* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000001800429
nkx3.2 / NK3 homeobox 2 / P78367*ENSDARG0000003763924
nkx3.3 / NK3 homeobox 3ENSDARG0000006932723
hmx2 / H6 family homeobox 2 / A2RU54* / P43687* / Homeobox protein HMX2 *ENSDARG0000007095418
hmx3b / H6 family homeobox 3bENSDARG0000009671618
hmx4 / H6 family homeobox 4ENSDARG0000000794118
nkx3-1 / NK3 homeobox 1 / P97436* / Q99801*ENSDARG0000007828018
hmx1 / H6 family homeobox 1 / O70218* / Q9NP08* / Homeobox protein HMX1 *ENSDARG0000009565117
hmx3a / H6 family homeobox 3a / HMX3* / P42581* / A6NHT5* / H6 family homeobox 3* / Homeobox protein HMX3 *ENSDARG0000007095517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0008347 glial cell migration IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IGI
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IMP
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0033504 floor plate development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord has extra parts of type oligodendrocyte , abnormal
spinal cord has fewer parts of type oligodendrocyte , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000778 spinal cord interneuron spinal cord interneuron cellular quality , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001256 lateral floor plate lateral floor plate Kolmer-Agduhr neuron cellular quality , abnormal
lateral floor plate GABAergic neuron absent , abnormal
lateral floor plate composition , abnormal
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 ZFA:0001260 endocrine pancreas endocrine pancreas physical object quality , abnormal
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 ZFA:0001372 pancreatic duct pancreatic duct aplastic , abnormal
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 ZFA:0009052 motor neuron motor neuron mislocalised , abnormal
motor neuron axon defasciculated , abnormal
motor neuron axon decreased thickness , abnormal
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 ZFA:0009073 glial cell glial cell mislocalised , abnormal
glial cell bicellular tight junction absent , abnormal
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 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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