ENSDARG00000070954


Danio rerio

Features
Gene ID: ENSDARG00000070954
  
Biological name :hmx2
  
Synonyms : H6 family homeobox 2 / hmx2
  
Possible biological names infered from orthology : A2RU54 / Homeobox protein HMX2 / P43687
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 21782043
Gene end: 21784152
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000108860
NCBI entrez gene - 555632     See in Manteia.
swissprot - F1QTJ6
ZFIN ID - ZDB-GENE-080506-2
Ensembl - ENSDARG00000070954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMX2ENSGALG00000030875Gallus gallus
 HMX2ENSG00000188816Homo sapiens
 Hmx2ENSMUSG00000050100Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hmx3a / H6 family homeobox 3a / HMX3* / P42581* / A6NHT5* / H6 family homeobox 3* / Homeobox protein HMX3 *ENSDARG0000007095538
hmx1 / H6 family homeobox 1 / O70218* / Q9NP08* / Homeobox protein HMX1 *ENSDARG0000009565131
hmx3b / H6 family homeobox 3bENSDARG0000009671630
hmx4 / H6 family homeobox 4ENSDARG0000000794129
nkx3.2 / NK3 homeobox 2 / P78367*ENSDARG0000003763922
nkx3.3 / NK3 homeobox 3ENSDARG0000006932722
nkx3-1 / NK3 homeobox 1 / P97436* / Q99801*ENSDARG0000007828019
nkx2.7 / NK2 transcription factor related 7 / Q8TAU0* / NKX2-6* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-5* / NK2 homeobox 3* / NK2 homeobox 5* / NK2 homeobox 6* /...ENSDARG0000002123219
nkx2.3 / NK2 homeobox 3 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-5* / NKX2-6* / NK2 homeobox 5* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000003909519
Q90481 / nkx2.2a / NK2 homeobox 2a / NKX2-2* / O95096* / NK2 homeobox 2*ENSDARG0000005329818
nkx2.5 / NK2 homeobox 5 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-6* / NK2 homeobox 3* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000001800418
nkx2.4a / NK2 homeobox 4aENSDARG0000007510718
nkx2.2b / NK2 homeobox 2bENSDARG0000010154917
nkx2.1 / NK2 homeobox 1 / Q9H2Z4* / P43699* / P50220* / Q9EQM3* / NKX2-4* / NK2 homeobox 4* / Homeobox protein Nkx-2.1 * / Homeobox protein Nkx-2.4 *ENSDARG0000001983517
nkx2.4b / NK2 homeobox 4bENSDARG0000010410717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0048916 posterior lateral line development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000168 anterior macula anterior macula mislocalised posteriorly , abnormal
anterior macula fused with posterior macula , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0000386 macula macula neuromast hair cell decreased amount , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal decreased size , abnormal
Show

 ZFA:0000530 lapillus lapillus fused with sagitta , abnormal
lapillus mislocalised , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula decreased amount , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast absent , abnormal
posterior lateral line neuromast decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism balance , abnormal
whole organism decreased coordination , abnormal
Show

 ZFA:0001617 otolith otolith located in saccule , abnormal
otolith fused with otolith , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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