ENSG00000119919


Homo sapiens

Features
Gene ID: ENSG00000119919
  
Biological name :NKX2-3
  
Synonyms : NK2 homeobox 3 / NKX2-3 / Q8TAU0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.2
Gene start: 99532933
Gene end: 99536524
  
Corresponding Affymetrix probe sets: 1553808_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342828
Ensembl peptide - ENSP00000479692
NCBI entrez gene - 159296     See in Manteia.
OMIM - 606727
RefSeq - NM_145285
RefSeq Peptide - NP_660328
swissprot - A0A087WVU3
swissprot - Q8TAU0
Ensembl - ENSG00000119919
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx2.3ENSDARG00000039095Danio rerio
 nkx2.5ENSDARG00000018004Danio rerio
 nkx2.7ENSDARG00000021232Danio rerio
 NKX2-3ENSGALG00000030932Gallus gallus
 Nkx2-3ENSMUSG00000044220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX2-5 / P52952 / NK2 homeobox 5ENSG0000018307243
A6NCS4 / NKX2-6 / NK2 homeobox 6ENSG0000018005342
NKX2-4 / Q9H2Z4 / NK2 homeobox 4ENSG0000012581631
NKX2-1 / P43699 / NK2 homeobox 1ENSG0000013635230
NKX2-2 / O95096 / NK2 homeobox 2ENSG0000012582029
NKX2-8 / O15522 / NK2 homeobox 8ENSG0000013632724
NKX3-2 / P78367 / NK3 homeobox 2ENSG0000010970524
NKX3-1 / Q99801 / NK3 homeobox 1ENSG0000016703420
HMX1 / Q9NP08 / H6 family homeobox 1ENSG0000021561219
HMX3 / A6NHT5 / H6 family homeobox 3ENSG0000018862019
HMX2 / A2RU54 / H6 family homeobox 2ENSG0000018881617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IEA
 biological_processGO:0002317 plasma cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030225 macrophage differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048535 lymph node development IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048537 mucosal-associated lymphoid tissue development IEA
 biological_processGO:0048541 Peyer"s patch development IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048621 post-embryonic digestive tract morphogenesis IEA
 biological_processGO:0050900 leukocyte migration IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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