ENSG00000167034


Homo sapiens

Features
Gene ID: ENSG00000167034
  
Biological name :NKX3-1
  
Synonyms : NK3 homeobox 1 / NKX3-1 / Q99801
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.2
Gene start: 23678693
Gene end: 23682927
  
Corresponding Affymetrix probe sets: 209706_at (Human Genome U133 Plus 2.0 Array)   211497_x_at (Human Genome U133 Plus 2.0 Array)   211498_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370253
Ensembl peptide - ENSP00000429729
NCBI entrez gene - 4824     See in Manteia.
OMIM - 602041
RefSeq - NM_001256339
RefSeq - NM_006167
RefSeq Peptide - NP_001243268
RefSeq Peptide - NP_006158
swissprot - Q99801
Ensembl - ENSG00000167034
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx3-1ENSDARG00000078280Danio rerio
 Nkx3-1ENSMUSG00000022061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX3-2 / P78367 / NK3 homeobox 2ENSG0000010970537
NKX2-3 / Q8TAU0 / NK2 homeobox 3ENSG0000011991931
HMX1 / Q9NP08 / H6 family homeobox 1ENSG0000021561228
A6NCS4 / NKX2-6 / NK2 homeobox 6ENSG0000018005328
NKX2-5 / P52952 / NK2 homeobox 5ENSG0000018307226
NKX2-4 / Q9H2Z4 / NK2 homeobox 4ENSG0000012581626
HMX3 / A6NHT5 / H6 family homeobox 3ENSG0000018862026
NKX2-1 / P43699 / NK2 homeobox 1ENSG0000013635224
HMX2 / A2RU54 / H6 family homeobox 2ENSG0000018881624
NKX2-2 / O95096 / NK2 homeobox 2ENSG0000012582024
NKX2-8 / O15522 / NK2 homeobox 8ENSG0000013632723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001655 urogenital system development IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007431 salivary gland development ISS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0030521 androgen receptor signaling pathway IDA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033574 response to testosterone ISS
 biological_processGO:0035690 cellular response to drug IEP
 biological_processGO:0035907 dorsal aorta development IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISS
 biological_processGO:0051781 positive regulation of cell division IMP
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060442 branching involved in prostate gland morphogenesis ISS
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis ISS
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development ISS
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071383 cellular response to steroid hormone stimulus IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:0071899 negative regulation of estrogen receptor binding IDA
 biological_processGO:2000836 positive regulation of androgen secretion IDA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IDA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004882 androgen receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA
 molecular_functionGO:0030284 estrogen receptor activity IDA
 molecular_functionGO:0030295 protein kinase activator activity IDA
 molecular_functionGO:0030331 estrogen receptor binding IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0097162 MADS box domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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