ENSMUSG00000044220


Mus musculus

Features
Gene ID: ENSMUSG00000044220
  
Biological name :Nkx2-3
  
Synonyms : Homeobox protein Nkx-2.3 / Nkx2-3 / P97334
  
Possible biological names infered from orthology : NK2 homeobox 3 / Q8TAU0
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 43612325
Gene end: 43615892
  
Corresponding Affymetrix probe sets: 10463277 (MoGene1.0st)   1425827_at (Mouse Genome 430 2.0 Array)   1427741_x_at (Mouse Genome 430 2.0 Array)   1452528_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050933
NCBI entrez gene - 18089     See in Manteia.
MGI - MGI:97348
RefSeq - NM_008699
RefSeq Peptide - NP_032725
swissprot - P97334
Ensembl - ENSMUSG00000044220
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx2.3ENSDARG00000039095Danio rerio
 nkx2.5ENSDARG00000018004Danio rerio
 nkx2.7ENSDARG00000021232Danio rerio
 NKX2-3ENSGALG00000030932Gallus gallus
 NKX2-3ENSG00000119919Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*ENSMUSG0000001557943
Nkx2-6 / P43688 / Homeobox protein Nkx-2.6 / A6NCS4* / NK2 homeobox 6*ENSMUSG0000004418635
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*ENSMUSG0000005416030
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*ENSMUSG0000000149629
Nkx2-2 / P42586 / NK2 homeobox 2 / O95096*ENSMUSG0000002743428
Nkx3-2 / P97503 / Homeobox protein Nkx-3.2 / P78367* / NK3 homeobox 2*ENSMUSG0000004969123
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*ENSMUSG0000005866922
Hmx1 / O70218 / Homeobox protein HMX1 / Q9NP08* / H6 family homeobox 1*ENSMUSG0000006743818
Nkx3-1 / P97436 / NK3 homeobox 1 / Q99801*ENSMUSG0000002206118
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*ENSMUSG0000004014818
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*ENSMUSG0000005010017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IMP
 biological_processGO:0002317 plasma cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0022612 gland morphogenesis IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048537 mucosal-associated lymphoid tissue development IMP
 biological_processGO:0048541 Peyer"s patch development IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048621 post-embryonic digestive tract morphogenesis IMP
 biological_processGO:0050900 leukocyte migration IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000328 increased intestinal cell number "greater than expected number of terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000478 delayed intestine development "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0002252 abnormal oropharynx morphology "structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002363 abnormal spleen marginal sinus morphology "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003289 abnormal intestinal peristalsis "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004035 abnormal sublingual gland morphology "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006400 decreased molar number "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha
Genetic Background: involves: 129S4/SvJae

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0009477 small cecum "reduced size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0013483 abnormal jejunum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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