MP:0000116 | abnormal tooth development | "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000121 | failure of tooth eruption | "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000328 | increased intestinal cell number | "greater than expected number of terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000478 | delayed intestine development | "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0000690 | absent spleen | "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0002252 | abnormal oropharynx morphology | "structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002356 | abnormal spleen red pulp morphology | "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002358 | abnormal spleen periarteriolar lymphoid sheath morphology | "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002363 | abnormal spleen marginal sinus morphology | "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0002378 | abnormal gut-associated lymphoid tissue morphology | "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002389 | abnormal Peyer s patch follicle morphology | "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0002581 | abnormal ileum morphology | "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002791 | steatorrhea | "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167] |
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0003156 | abnormal lymphocyte migration/homing | "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0003289 | abnormal intestinal peristalsis | "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0003643 | spleen atrophy | "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0004002 | abnormal jejunum morphology | "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0004035 | abnormal sublingual gland morphology | "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0004953 | decreased spleen weight | "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0005036 | diarrhea | "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0005232 | abnormal mesenteric lymph node morphology | "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0006400 | decreased molar number | "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008098 | decreased plasma cell number | "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008133 | decreased Peyer s patch number | "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008135 | small Peyer s patches | "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008180 | abnormal marginal zone B cell morphology | "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0008183 | absent marginal zone B cells | "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0008234 | absent spleen marginal zone | "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008240 | abnormal spleen marginal zone macrophage morphology | "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0008241 | abnormal metallophilic macrophage morphology | "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748] |
Show
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008471 | abnormal spleen primary B follicle morphology | "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967] |
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Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0008475 | intermingled spleen red and white pulp | "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0008479 | decreased spleen white pulp amount | "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Hha/Nkx2-3tm1Hha Genetic Background: involves: 129S4/SvJae
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MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
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MP:0009477 | small cecum | "reduced size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0013483 | abnormal jejunum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0030457 | abnormal molar cusp morphology | "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna] |
Show
Allelic Composition: Nkx2-3tm1Rph/Nkx2-3tm1Rph Genetic Background: involves: 129S1/Sv * C57BL/6
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