ENSG00000136450


Homo sapiens

Features
Gene ID: ENSG00000136450
  
Biological name :SRSF1
  
Synonyms : Q07955 / serine and arginine rich splicing factor 1 / SRSF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q22
Gene start: 58003360
Gene end: 58007346
  
Corresponding Affymetrix probe sets: 201741_x_at (Human Genome U133 Plus 2.0 Array)   201742_x_at (Human Genome U133 Plus 2.0 Array)   208863_s_at (Human Genome U133 Plus 2.0 Array)   211784_s_at (Human Genome U133 Plus 2.0 Array)   227164_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462616
Ensembl peptide - ENSP00000462687
Ensembl peptide - ENSP00000463042
Ensembl peptide - ENSP00000463223
Ensembl peptide - ENSP00000463917
Ensembl peptide - ENSP00000258962
Ensembl peptide - ENSP00000462215
NCBI entrez gene - 6426     See in Manteia.
OMIM - 600812
RefSeq - NM_006924
RefSeq - NM_001078166
RefSeq Peptide - NP_001071634
RefSeq Peptide - NP_008855
swissprot - Q07955
swissprot - J3KSR8
swissprot - J3KSW7
swissprot - J3KTL2
swissprot - J3QQV5
Ensembl - ENSG00000136450
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SXP4ENSDARG00000057691Danio rerio
 SRSF1ENSGALG00000005525Gallus gallus
 Srsf1ENSMUSG00000018379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SRSF9 / Q13242 / serine and arginine rich splicing factor 9ENSG0000011178663
SRSF4 / Q08170 / serine and arginine rich splicing factor 4ENSG0000011635047
SRSF6 / Q13247 / serine and arginine rich splicing factor 6ENSG0000012419346
SRSF5 / Q13243 / serine and arginine rich splicing factor 5ENSG0000010065042


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR029538  Serine/arginine-rich splicing factor 1
 IPR034520  SRSF1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IDA
 biological_processGO:0000395 mRNA 5"-splice site recognition IDA
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006376 mRNA splice site selection TAS
 biological_processGO:0006397 mRNA processing TAS
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0097421 liver regeneration IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0035145 exon-exon junction complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0044547 DNA topoisomerase binding IPI
 molecular_functionGO:0050733 RS domain binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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