ENSMUSG00000018379


Mus musculus

Features
Gene ID: ENSMUSG00000018379
  
Biological name :Srsf1
  
Synonyms : Q6PDM2 / Serine/arginine-rich splicing factor 1 / Srsf1
  
Possible biological names infered from orthology : Q07955 / serine and arginine rich splicing factor 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 88047373
Gene end: 88053755
  
Corresponding Affymetrix probe sets: 10380210 (MoGene1.0st)   1428099_a_at (Mouse Genome 430 2.0 Array)   1428100_at (Mouse Genome 430 2.0 Array)   1430982_at (Mouse Genome 430 2.0 Array)   1434972_x_at (Mouse Genome 430 2.0 Array)   1452430_s_at (Mouse Genome 430 2.0 Array)   1453722_s_at (Mouse Genome 430 2.0 Array)   1457136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133517
Ensembl peptide - ENSMUSP00000103553
Ensembl peptide - ENSMUSP00000120595
Ensembl peptide - ENSMUSP00000114549
Ensembl peptide - ENSMUSP00000128190
NCBI entrez gene - 110809     See in Manteia.
MGI - MGI:98283
RefSeq - NM_001078167
RefSeq - NM_173374
RefSeq Peptide - NP_001071635
RefSeq Peptide - NP_775550
swissprot - Q6PDM2
swissprot - F6QXN3
swissprot - F7AI47
swissprot - H7BX95
Ensembl - ENSMUSG00000018379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SXP4ENSDARG00000057691Danio rerio
 SRSF1ENSGALG00000005525Gallus gallus
 SRSF1ENSG00000136450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srsf9 / Q9D0B0 / Serine/arginine-rich splicing factor 9 / Q13242* / serine and arginine rich splicing factor 9*ENSMUSG0000002953863
Srsf4 / serine/arginine-rich splicing factor 4 / Q08170* / serine and arginine rich splicing factor 4*ENSMUSG0000002891147
Srsf6 / Q3TWW8 / serine/arginine-rich splicing factor 6 / Q13247* / serine and arginine rich splicing factor 6*ENSMUSG0000001692146
Srsf5 / O35326 / serine/arginine-rich splicing factor 5 / Q13243* / serine and arginine rich splicing factor 5*ENSMUSG0000002113442


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR029538  Serine/arginine-rich splicing factor 1
 IPR034520  SRSF1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome ISO
 biological_processGO:0000395 mRNA 5"-splice site recognition ISS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IGI
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0060048 cardiac muscle contraction IGI
 biological_processGO:0097421 liver regeneration IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0035145 exon-exon junction complex ISO
 cellular_componentGO:0071013 catalytic step 2 spliceosome ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0044547 DNA topoisomerase binding ISO
 molecular_functionGO:0050733 RS domain binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010235 abnormal retina inner limiting membrane morphology "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Nrg1tm2Zhou/Nrg1tm2Zhou
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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