ENSG00000158270


Homo sapiens

Features
Gene ID: ENSG00000158270
  
Biological name :COLEC12
  
Synonyms : COLEC12 / collectin subfamily member 12 / Q5KU26
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: p11.32
Gene start: 316740
Gene end: 500722
  
Corresponding Affymetrix probe sets: 221019_s_at (Human Genome U133 Plus 2.0 Array)   240397_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383115
NCBI entrez gene - 81035     See in Manteia.
OMIM - 607621
RefSeq - NM_130386
RefSeq - XM_011525741
RefSeq Peptide - NP_569057
swissprot - Q5KU26
Ensembl - ENSG00000158270
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5PMY6ENSDARG00000061140Danio rerio
 COLEC12ENSGALG00000014910Gallus gallus
 Q8K4Q8ENSMUSG00000036103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6AZY7 / SCARA3 / scavenger receptor class A member 3ENSG0000016807728
Q9UMD9 / COL17A1 / collagen type XVII alpha 1 chainENSG0000006561818
COL6A2 / P12110 / collagen type VI alpha 2 chainENSG0000014217317
Q2UY09 / COL28A1 / collagen type XXVIII alpha 1 chainENSG0000021501817
COL6A1 / P12109 / collagen type VI alpha 1 chainENSG0000014215617
COLQ / Q9Y215 / collagen like tail subunit of asymmetric acetylcholinesteraseENSG0000020656112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006910 phagocytosis, recognition IDA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009756 carbohydrate mediated signaling NAS
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IMP
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0051260 protein homooligomerization NAS
 biological_processGO:0060355 positive regulation of cell adhesion molecule production IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005534 galactose binding NAS
 molecular_functionGO:0008329 signaling pattern recognition receptor activity IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000085514 PILRA / Q9UKJ1 / paired immunoglobin like type 2 receptor alpha  / complex / reaction
 ENSG00000158270 Q5KU26 / COLEC12 / collectin subfamily member 12  / complex






 

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