ENSG00000170004


Homo sapiens

Features
Gene ID: ENSG00000170004
  
Biological name :CHD3
  
Synonyms : CHD3 / chromodomain helicase DNA binding protein 3 / Q12873
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7884806
Gene end: 7912760
  
Corresponding Affymetrix probe sets: 208806_at (Human Genome U133 Plus 2.0 Array)   208807_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467547
Ensembl peptide - ENSP00000458861
Ensembl peptide - ENSP00000459321
Ensembl peptide - ENSP00000332628
Ensembl peptide - ENSP00000350907
Ensembl peptide - ENSP00000369716
Ensembl peptide - ENSP00000395252
Ensembl peptide - ENSP00000405861
Ensembl peptide - ENSP00000411959
NCBI entrez gene - 1107     See in Manteia.
OMIM - 602120
RefSeq - XM_017024070
RefSeq - XM_006721428
RefSeq - XM_017024061
RefSeq - XM_017024062
RefSeq - XM_017024063
RefSeq - XM_017024064
RefSeq - XM_017024065
RefSeq - XM_017024066
RefSeq - XM_017024067
RefSeq - XM_017024068
RefSeq - XM_017024069
RefSeq - NM_001005271
RefSeq - NM_001005273
RefSeq - NM_005852
RefSeq - XM_005256427
RefSeq - XM_005256428
RefSeq - XM_005256429
RefSeq - XM_006721423
RefSeq - XM_006721424
RefSeq Peptide - NP_001005273
RefSeq Peptide - NP_005843
RefSeq Peptide - NP_001005271
swissprot - I3L229
swissprot - K7EPV1
swissprot - H7C2H0
swissprot - Q12873
swissprot - H7C0J3
swissprot - H7C3H7
swissprot - I3L1I4
Ensembl - ENSG00000170004
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd3ENSDARG00000021405Danio rerio
 Chd3ENSMUSG00000018474Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHD5 / Q8TDI0 / chromodomain helicase DNA binding protein 5ENSG0000011625467
CHD4 / Q14839 / chromodomain helicase DNA binding protein 4ENSG0000011164265
CHD7 / Q9P2D1 / chromodomain helicase DNA binding protein 7ENSG0000017131625
CHD2 / O14647 / chromodomain helicase DNA binding protein 2ENSG0000017357524
CHD1 / O14646 / chromodomain helicase DNA binding protein 1ENSG0000015392224
CHD9 / Q3L8U1 / chromodomain helicase DNA binding protein 9ENSG0000017720023
CHD6 / Q8TD26 / chromodomain helicase DNA binding protein 6ENSG0000012417723
CHD8 / Q9HCK8 / chromodomain helicase DNA binding protein 8ENSG0000010088823
AC013394.1ENSG000002797651


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR001965  Zinc finger, PHD-type
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR009462  Domain of unknown function DUF1086
 IPR009463  Domain of unknown function DUF1087
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR012957  CHD, C-terminal 2
 IPR012958  CHD, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028722  Chromodomain-helicase-DNA-binding protein 3
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016581 NuRD complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity NAS
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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