ENSG00000116254


Homo sapiens

Features
Gene ID: ENSG00000116254
  
Biological name :CHD5
  
Synonyms : CHD5 / chromodomain helicase DNA binding protein 5 / Q8TDI0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.31
Gene start: 6101793
Gene end: 6180123
  
Corresponding Affymetrix probe sets: 213965_s_at (Human Genome U133 Plus 2.0 Array)   217250_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367238
Ensembl peptide - ENSP00000433676
Ensembl peptide - ENSP00000466440
Ensembl peptide - ENSP00000466706
Ensembl peptide - ENSP00000468624
Ensembl peptide - ENSP00000262450
NCBI entrez gene - 26038     See in Manteia.
OMIM - 610771
RefSeq - NM_015557
RefSeq Peptide - NP_056372
swissprot - Q8TDI0
swissprot - F2Z2R5
swissprot - F6T542
swissprot - K7EMC0
swissprot - K7EMY3
swissprot - K7ESA5
Ensembl - ENSG00000116254
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd5ENSDARG00000105083Danio rerio
 ENSGALG00000040077Gallus gallus
 ENSGALG00000000747Gallus gallus
 Chd5ENSMUSG00000005045Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHD3 / Q12873 / chromodomain helicase DNA binding protein 3ENSG0000017000470
CHD4 / Q14839 / chromodomain helicase DNA binding protein 4ENSG0000011164270
CHD2 / O14647 / chromodomain helicase DNA binding protein 2ENSG0000017357526
CHD1 / O14646 / chromodomain helicase DNA binding protein 1ENSG0000015392225
CHD7 / Q9P2D1 / chromodomain helicase DNA binding protein 7ENSG0000017131625
CHD6 / Q8TD26 / chromodomain helicase DNA binding protein 6ENSG0000012417724
CHD9 / Q3L8U1 / chromodomain helicase DNA binding protein 9ENSG0000017720024
CHD8 / Q9HCK8 / chromodomain helicase DNA binding protein 8ENSG0000010088824
AC013394.1ENSG000002797651


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR001965  Zinc finger, PHD-type
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR009462  Domain of unknown function DUF1086
 IPR009463  Domain of unknown function DUF1087
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR012957  CHD, C-terminal 2
 IPR012958  CHD, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028727  Chromodomain-helicase-DNA-binding protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0021895 cerebral cortex neuron differentiation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins ISS
 biological_processGO:0043967 histone H4 acetylation ISS
 biological_processGO:0060850 regulation of transcription involved in cell fate commitment IMP
 biological_processGO:0098532 histone H3-K27 trimethylation IMP
 biological_processGO:1901798 positive regulation of signal transduction by p53 class mediator ISS
 cellular_componentGO:0000792 heterochromatin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016581 NuRD complex ISS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061628 H3K27me3 modified histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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