ENSMUSG00000005045


Mus musculus

Features
Gene ID: ENSMUSG00000005045
  
Biological name :Chd5
  
Synonyms : A2A8L1 / Chd5 / Chromodomain-helicase-DNA-binding protein 5
  
Possible biological names infered from orthology : Q8TDI0
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152338651
Gene end: 152390194
  
Corresponding Affymetrix probe sets: 10510725 (MoGene1.0st)   1436095_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030775
Ensembl peptide - ENSMUSP00000132600
Ensembl peptide - ENSMUSP00000005175
NCBI entrez gene - 269610     See in Manteia.
MGI - MGI:3036258
RefSeq - XM_017320245
RefSeq - XM_006538932
RefSeq - XM_006538933
RefSeq - XM_006538934
RefSeq - XM_006538935
RefSeq - XM_017320244
RefSeq - NM_001081376
RefSeq - NM_029216
RefSeq - XM_006538929
RefSeq - XM_006538930
RefSeq - XM_006538931
RefSeq Peptide - NP_083492
RefSeq Peptide - NP_001074845
swissprot - E9PYU4
swissprot - E9PYL1
swissprot - A2A8L1
Ensembl - ENSMUSG00000005045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd5ENSDARG00000105083Danio rerio
 ENSGALG00000040077Gallus gallus
 ENSGALG00000000747Gallus gallus
 CHD5ENSG00000116254Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847470
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*ENSMUSG0000006387069
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*ENSMUSG0000007867126
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*ENSMUSG0000002385225
Chd7 / A2AJK6 / Chromodomain-helicase-DNA-binding protein 7 / Q9P2D1*ENSMUSG0000004123525
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660825
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*ENSMUSG0000005375425
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR001965  Zinc finger, PHD-type
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR009462  Domain of unknown function DUF1086
 IPR009463  Domain of unknown function DUF1087
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR012957  CHD, C-terminal 2
 IPR012958  CHD, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028727  Chromodomain-helicase-DNA-binding protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0021895 cerebral cortex neuron differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 biological_processGO:0043967 histone H4 acetylation IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0060850 regulation of transcription involved in cell fate commitment IEA
 biological_processGO:0098532 histone H3-K27 trimethylation IEA
 biological_processGO:1901798 positive regulation of signal transduction by p53 class mediator IMP
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016581 NuRD complex IDA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061628 H3K27me3 modified histone binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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