ENSMUSG00000063870


Mus musculus

Features
Gene ID: ENSMUSG00000063870
  
Biological name :Chd4
  
Synonyms : Chd4 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q6PDQ2
  
Possible biological names infered from orthology : chromodomain helicase DNA binding protein 4 / Q14839
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 125095981
Gene end: 125130591
  
Corresponding Affymetrix probe sets: 10541803 (MoGene1.0st)   1436343_at (Mouse Genome 430 2.0 Array)   1438476_a_at (Mouse Genome 430 2.0 Array)   1451295_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060054
Ensembl peptide - ENSMUSP00000108011
Ensembl peptide - ENSMUSP00000120704
Ensembl peptide - ENSMUSP00000122806
Ensembl peptide - ENSMUSP00000108009
NCBI entrez gene - 107932     See in Manteia.
MGI - MGI:1344380
RefSeq - XM_017321296
RefSeq - XM_006505284
RefSeq - XM_006505285
RefSeq - XM_006505286
RefSeq - XM_006505287
RefSeq - XM_017321292
RefSeq - XM_017321294
RefSeq - XM_017321295
RefSeq - NM_001346610
RefSeq - NM_145979
RefSeq - XM_006505280
RefSeq - XM_006505281
RefSeq - XM_006505282
RefSeq - XM_006505283
RefSeq Peptide - NP_001333539
RefSeq Peptide - NP_666091
swissprot - E9QAS5
swissprot - F6WR45
swissprot - E9QAS4
swissprot - Q6PDQ2
swissprot - G5E8V7
Ensembl - ENSMUSG00000063870
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd4aENSDARG00000063535Danio rerio
 chd4bENSDARG00000025789Danio rerio
 CHD4ENSGALG00000013565Gallus gallus
 CHD4ENSG00000111642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*ENSMUSG0000000504571
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847469
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*ENSMUSG0000007867126
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660825
Chd7 / A2AJK6 / Chromodomain-helicase-DNA-binding protein 7 / Q9P2D1*ENSMUSG0000004123525
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713324
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*ENSMUSG0000005375424
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*ENSMUSG0000002385224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR001965  Zinc finger, PHD-type
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR009462  Domain of unknown function DUF1086
 IPR009463  Domain of unknown function DUF1087
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR012957  CHD, C-terminal 2
 IPR012958  CHD, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0072553 terminal button organization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016581 NuRD complex ISO
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Chd4tm1.1Kge/Chd4tm1.1Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Chd4tm1.1Kge/Chd4tm1.2Kge,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Chd4tm1.1Kge/Chd4tm1.1Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd4tm1.1Kge/Chd4tm1.1Kge,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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