ENSMUSG00000053754


Mus musculus

Features
Gene ID: ENSMUSG00000053754
  
Biological name :Chd8
  
Synonyms : Chd8 / Chromodomain-helicase-DNA-binding protein 8 / Q09XV5
  
Possible biological names infered from orthology : Q9HCK8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 52198151
Gene end: 52257780
  
Corresponding Affymetrix probe sets: 10419638 (MoGene1.0st)   1437297_at (Mouse Genome 430 2.0 Array)   1443711_at (Mouse Genome 430 2.0 Array)   1443900_at (Mouse Genome 430 2.0 Array)   1457580_at (Mouse Genome 430 2.0 Array)   1457712_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142890
Ensembl peptide - ENSMUSP00000087184
Ensembl peptide - ENSMUSP00000122995
Ensembl peptide - ENSMUSP00000154509
Ensembl peptide - ENSMUSP00000154595
NCBI entrez gene - 67772     See in Manteia.
MGI - MGI:1915022
RefSeq - XM_017316172
RefSeq - NM_201637
RefSeq - XM_011245165
RefSeq - XM_017316170
RefSeq - XM_017316171
RefSeq - XM_006519476
RefSeq Peptide - NP_963999
swissprot - Q09XV5
swissprot - F7AL76
Ensembl - ENSMUSG00000053754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd8ENSDARG00000075543Danio rerio
 CHD8ENSG00000100888Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd7 / A2AJK6 / Chromodomain-helicase-DNA-binding protein 7 / Q9P2D1*ENSMUSG0000004123551
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660851
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713342
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*ENSMUSG0000000504519
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*ENSMUSG0000006387018
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847418
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*ENSMUSG0000007867117
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*ENSMUSG0000002385216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR034724  Chromodomain-helicase-DNA-binding protein 8
 IPR037259  BRK domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development ISO
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III ISS
 biological_processGO:0048565 digestive tract development ISO
 biological_processGO:0060070 canonical Wnt signaling pathway ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0071339 MLL1 complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003678 DNA helicase activity ISS
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008013 beta-catenin binding ISS
 molecular_functionGO:0008094 DNA-dependent ATPase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr