ENSMUSG00000023852


Mus musculus

Features
Gene ID: ENSMUSG00000023852
  
Biological name :Chd1
  
Synonyms : Chd1 / Chromodomain-helicase-DNA-binding protein 1 / P40201 / Q9CQS5
  
Possible biological names infered from orthology : O14646
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A2
Gene start: 15704967
Gene end: 17394898
  
Corresponding Affymetrix probe sets: 10441987 (MoGene1.0st)   10442057 (MoGene1.0st)   1420990_at (Mouse Genome 430 2.0 Array)   1423481_at (Mouse Genome 430 2.0 Array)   1431166_at (Mouse Genome 430 2.0 Array)   1436684_a_at (Mouse Genome 430 2.0 Array)   1440381_at (Mouse Genome 430 2.0 Array)   1450077_at (Mouse Genome 430 2.0 Array)   1457473_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134091
Ensembl peptide - ENSMUSP00000134718
Ensembl peptide - ENSMUSP00000024627
Ensembl peptide - ENSMUSP00000133406
Ensembl peptide - ENSMUSP00000024620
NCBI entrez gene - 67045     See in Manteia.
NCBI entrez gene - 12648     See in Manteia.
MGI - MGI:88393
RefSeq - NM_025934
RefSeq - NM_007690
RefSeq Peptide - NP_031716
RefSeq Peptide - NP_080210
swissprot - Q9CQS5
swissprot - G3UWS6
swissprot - G3V014
swissprot - P40201
swissprot - Q8C7Q2
Ensembl - ENSMUSG00000023852
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd1ENSDARG00000103787Danio rerio
 ENSGALG00000031327Gallus gallus
 CHD1ZENSGALG00000014642Gallus gallus
 CHD1ENSG00000153922Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*ENSMUSG0000007867161
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*ENSMUSG0000000504529
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847428
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*ENSMUSG0000006387027
Chd7 / A2AJK6 / Chromodomain-helicase-DNA-binding protein 7 / Q9P2D1*ENSMUSG0000004123525
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660825
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*ENSMUSG0000005375424
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000687  RIO kinase
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR011009  Protein kinase-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR015285  RIO2 kinase winged helix domain, N-terminal
 IPR016197  Chromo-like domain superfamily
 IPR018935  RIO kinase, conserved site
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR025260  Domain of unknown function DUF4208
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030484  Serine/threonine-protein kinase Rio2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly NAS
 biological_processGO:0006338 chromatin remodeling IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016569 covalent chromatin modification IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition ISS
 biological_processGO:0030490 maturation of SSU-rRNA ISO
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042274 ribosomal small subunit biogenesis ISO
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:2000208 positive regulation of ribosomal small subunit export from nucleus ISO
 biological_processGO:2000234 positive regulation of rRNA processing ISO
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030688 preribosome, small subunit precursor ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding NAS
 molecular_functionGO:0004386 helicase activity NAS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

Allelic Composition: Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr