ENSMUSG00000078671


Mus musculus

Features
Gene ID: ENSMUSG00000078671
  
Biological name :Chd2
  
Synonyms : Chd2 / Chromodomain-helicase-DNA-binding protein 2 / E9PZM4
  
Possible biological names infered from orthology : O14647
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D1
Gene start: 73426638
Gene end: 73541830
  
Corresponding Affymetrix probe sets: 10564573 (MoGene1.0st)   1428691_at (Mouse Genome 430 2.0 Array)   1445843_at (Mouse Genome 430 2.0 Array)   1452991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134484
Ensembl peptide - ENSMUSP00000147180
Ensembl peptide - ENSMUSP00000143203
Ensembl peptide - ENSMUSP00000142959
Ensembl peptide - ENSMUSP00000142885
Ensembl peptide - ENSMUSP00000142848
Ensembl peptide - ENSMUSP00000142408
Ensembl peptide - ENSMUSP00000137985
Ensembl peptide - ENSMUSP00000026895
Ensembl peptide - ENSMUSP00000126352
Ensembl peptide - ENSMUSP00000133714
NCBI entrez gene - 244059     See in Manteia.
MGI - MGI:2448567
RefSeq - NM_001081345
RefSeq Peptide - NP_001074814
swissprot - A0A0G2JEZ3
swissprot - A0A0G2JES5
swissprot - A0A0G2JEP1
swissprot - A0A0G2JDK8
swissprot - E9PZM4
swissprot - G3UXJ4
swissprot - G3UZG2
swissprot - M0QWT0
swissprot - F7CDZ7
swissprot - A0A140LJE4
swissprot - A0A0G2JFK1
Ensembl - ENSMUSG00000078671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd2ENSDARG00000060687Danio rerio
 CHD2ENSGALG00000006949Gallus gallus
 CHD2ENSG00000173575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*ENSMUSG0000002385257
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*ENSMUSG0000006387028
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847427
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*ENSMUSG0000000504527
Chd7 / A2AJK6 / Chromodomain-helicase-DNA-binding protein 7 / Q9P2D1*ENSMUSG0000004123524
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713323
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*ENSMUSG0000005375423
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR025260  Domain of unknown function DUF4208
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002879 increased sensitivity to X-ray irradiation "increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008404 increased cellular sensitivity to methylmethanesulfonate "greater incidence of cell death following exposure to methylmethanesulfonate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010894 pulmonary alveolar edema "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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