Manteia - Molecule gene

ENSMUSG00000041235

Mus musculus

Features

Gene ID:	ENSMUSG00000041235

Biological name :	Chd7

Synonyms :	A2AJK6 / Chd7 / Chromodomain-helicase-DNA-binding protein 7

Possible biological names infered from orthology :	Q9P2D1

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	A1
Gene start:	8690406
Gene end:	8867659

Corresponding Affymetrix probe sets:	10503161 (MoGene1.0st) 10503166 (MoGene1.0st) 10503168 (MoGene1.0st) 10503170 (MoGene1.0st) 10503172 (MoGene1.0st) 10503174 (MoGene1.0st) 10503176 (MoGene1.0st) 10503178 (MoGene1.0st) 10503180 (MoGene1.0st) 10503182 (MoGene1.0st) 10503184 (MoGene1.0st) 10503186 (MoGene1.0st) 10503188 (MoGene1.0st) 10503190 (MoGene1.0st) 10503192 (MoGene1.0st) 10503194 (MoGene1.0st) 10503196 (MoGene1.0st) 10503198 (MoGene1.0st) 10503200 (MoGene1.0st) 10503202 (MoGene1.0st) 10503204 (MoGene1.0st) 10503206 (MoGene1.0st) 10503208 (MoGene1.0st) 10503210 (MoGene1.0st) 10503212 (MoGene1.0st) 10503214 (MoGene1.0st) 10503216 (MoGene1.0st) 10503218 (MoGene1.0st) 10503220 (MoGene1.0st) 10503222 (MoGene1.0st) 1437745_at (Mouse Genome 430 2.0 Array) 1448026_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000043903 Ensembl peptide - ENSMUSP00000152166 Ensembl peptide - ENSMUSP00000127007 Ensembl peptide - ENSMUSP00000123241 Ensembl peptide - ENSMUSP00000118711 Ensembl peptide - ENSMUSP00000059079 NCBI entrez gene - 320790 See in Manteia. MGI - MGI:2444748 RefSeq - XM_017320263 RefSeq - NM_001277149 RefSeq - XM_006538004 RefSeq - XM_006538005 RefSeq - XM_006538006 RefSeq Peptide - NP_001264078 swissprot - E9PV74 swissprot - A2AJK6 swissprot - A0A1Y7VIV0 swissprot - A0A0R4J1U9 swissprot - A2AJK7 Ensembl - ENSMUSG00000041235

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
chd7	ENSDARG00000075211	Danio rerio
CHD7	ENSGALG00000041080	Gallus gallus
CHD7	ENSG00000171316	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*	ENSMUSG00000056608	48
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*	ENSMUSG00000053754	44
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*	ENSMUSG00000057133	42
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*	ENSMUSG00000018474	17
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*	ENSMUSG00000005045	16
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*	ENSMUSG00000063870	16
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*	ENSMUSG00000078671	15
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*	ENSMUSG00000023852	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000330	SNF2-related, N-terminal domain
IPR000953	Chromo/chromo shadow domain
IPR001650	Helicase, C-terminal
IPR006576	BRK domain
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR016197	Chromo-like domain superfamily
IPR023780	Chromo domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR037259	BRK domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001501	skeletal system development	ISO
biological_process	GO:0001568	blood vessel development	IMP
biological_process	GO:0001701	in utero embryonic development	ISO
biological_process	GO:0001974	blood vessel remodeling	IMP
biological_process	GO:0003007	heart morphogenesis	ISO
biological_process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP
biological_process	GO:0003226	right ventricular compact myocardium morphogenesis	IMP
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006338	chromatin remodeling	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006364	rRNA processing	IEA
biological_process	GO:0007417	central nervous system development	ISO
biological_process	GO:0007512	adult heart development	IMP
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0007626	locomotory behavior	IMP
biological_process	GO:0007628	adult walking behavior	IMP
biological_process	GO:0008015	blood circulation	IMP
biological_process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP
biological_process	GO:0021545	cranial nerve development	ISO
biological_process	GO:0021553	olfactory nerve development	IMP
biological_process	GO:0021772	olfactory bulb development	IMP
biological_process	GO:0030217	T cell differentiation	ISO
biological_process	GO:0030540	female genitalia development	IMP
biological_process	GO:0035116	embryonic hindlimb morphogenesis	IMP
biological_process	GO:0035904	aorta development	IMP
biological_process	GO:0035909	aorta morphogenesis	IMP
biological_process	GO:0036302	atrioventricular canal development	IMP
biological_process	GO:0040018	positive regulation of multicellular organism growth	IMP
biological_process	GO:0042048	olfactory behavior	IMP
biological_process	GO:0042471	ear morphogenesis	IMP
biological_process	GO:0042472	inner ear morphogenesis	ISO
biological_process	GO:0043010	camera-type eye development	IMP
biological_process	GO:0043584	nose development	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0048752	semicircular canal morphogenesis	IGI
biological_process	GO:0048771	tissue remodeling	IMP
biological_process	GO:0048806	genitalia development	ISO
biological_process	GO:0048844	artery morphogenesis	IGI
biological_process	GO:0050767	regulation of neurogenesis	IMP
biological_process	GO:0050890	cognition	ISO
biological_process	GO:0060021	roof of mouth development	ISO
biological_process	GO:0060041	retina development in camera-type eye	ISO
biological_process	GO:0060123	regulation of growth hormone secretion	ISO
biological_process	GO:0060173	limb development	ISO
biological_process	GO:0060324	face development	ISO
biological_process	GO:0060384	innervation	IMP
biological_process	GO:0060411	cardiac septum morphogenesis	IMP
biological_process	GO:0060429	epithelium development	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005730	nucleolus	ISO
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0004386	helicase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016817	hydrolase activity, acting on acid anhydrides	IEA
molecular_function	GO:1990841	promoter-specific chromatin binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0000037	abnormal lateral semicircular canal	"anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tgfa^wa1/Tgfa^wa1 Genetic Background: Not Specified Allelic Composition: Chd7^Mt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Lda/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Dz/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Cycn/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: B6.C3Fe-Chd7^Whi Allelic Composition: Chd7^Whi/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: B6.Cg-Chd7^Whi Tbx1^tm1Bld
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0000300	thin endocardial cushion	"reduced thickness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [J:45302]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0000446	long snout	"the anterior facial part of the muzzle having a length greater than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0000486	abnormal pulmonary trunk morphology	"structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000556	abnormal hindlimb morphology	"malformation of the entire posterior extremities" [MGI:tc]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000794	abnormal parietal lobe morphology	"malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000798	abnormal frontal lobe morphology	"malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000809	absent hippocampus	"missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000825	dilated lateral ventricles	"increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
MP:0001056	abnormal cranial nerve morphology	"any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001074	abnormal vagus nerve morphology	"malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cenpj^{tm1a(EUCOMM)Wtsi}/Cenpj^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Cenpj^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: 129S5;B6N-Chd7^{tm2a(EUCOMM)Wtsi}/Wtsi
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tgfa^wa1/Tgfa^wa1 Genetic Background: Not Specified Allelic Composition: Chd7^Mt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Lda/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Dz/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Cycn/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Sod2^tm1Kskk/Sod2^tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2^tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Sod2^tm1Kskk/Sod2^tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2^tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl Allelic Composition: Chd7^tm1.1Dmm/Chd7^tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0 Genetic Background: involves: 129S6/SvEvTac * FVB
MP:0001337	dry eyes	"absence of natural or normal moisture in the eye" [J:53284]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0001388	abnormal stationary movement	"altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thpo^tm1Mwm/Thpo⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Tgfa^wa1/Tgfa^wa1 Genetic Background: Not Specified Allelic Composition: Chd7^Mt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Lda/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Dz/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Cycn/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^tm1.2Dmm/Chd7^tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0001395	bi-directional circling	"circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Fgfr3^tm1Dor/Fgfr3^tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: 129S5;B6N-Chd7^{tm2a(EUCOMM)Wtsi}/Wtsi
MP:0001410	head bobbing	"compulsive up and down movement of the head" [J:17123]	Show Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^tm1.2Dmm/Chd7^tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thpo^tm1Mwm/Thpo⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001522	impaired swimming	"reduced ability or inability to swim" [J:45446, J:39081]	Show Allelic Composition: Thpo^tm1Mwm/Thpo⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Thpo^tm1Mwm/Thpo⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001526	abnormal placing response	"altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]	Show Allelic Composition: Thpo^tm1Mwm/Thpo⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Rpe65^450L/Rpe65^450L Genetic Background: BALB/c
MP:0001850	otitis media	"middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0002177	abnormal outer ear morphology	"malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002236	abnormal internal nares morphology	"any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano,Chrm5^tm1Minm/Chrm5^tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^tm1.2Dmm/Chd7^tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002730	head shaking	"compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0002858	abnormal posterior semicircular canal	"anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tgfa^wa1/Tgfa^wa1 Genetic Background: Not Specified Allelic Composition: Chd7^Mt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Lda/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Dz/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Cycn/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: B6.C3Fe-Chd7^Whi Allelic Composition: Chd7^Whi/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: B6.Cg-Chd7^Whi Tbx1^tm1Bld
MP:0002859	abnormal canal fusion	"malformed or mistimed fusion of the canal primordia during development" [J:75619]	Show Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0002950	abnormal neural crest cell migration	"defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003007	ectopic thymus	"ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
MP:0003069	abnormal superior semicircular canal	"anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi
MP:0003126	abnormal vulva morphology	"anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0003148	reduced cochlear coiling	"a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0003161	absent lateral semicircular canal		Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: B6.C3Fe-Chd7^Whi Allelic Composition: Chd7^Whi/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: B6.Cg-Chd7^Whi Tbx1^tm1Bld Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0003162	reduced size of lateral semicircular canal		Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^tm1.1Dmm/Chd7⁺,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0003163	absent posterior semicircular canal		Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0003164	reduced size of posterior semicircular canal		Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0003166	reduced size of superior semicircular canal		Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0003222	increased cardiomyocyte apoptosis	"increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0003330	abnormal auditory tube	"anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0003387	coarctation of aorta	"narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003395	abnormal subclavian artery morphology	"malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
MP:0003451	absent olfactory bulb	"absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^tm1.1Dmm/Chd7⁺,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1) Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^tm1.1Dmm/Chd7⁺,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
MP:0004188	delayed embryo turning	"completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
MP:0004249	abnormal crista ampullaris morphology	"anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0004261	abnormal embryonic neuroepithelium morphology	"any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sod2^tm1Kskk/Sod2^tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2^tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
MP:0004290	abnormal stapes footplate	"any structural abnormality in the flat portion of the stapes that fits in the oval window" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0004315	absent saccule	"absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0004369	absent utricle	"absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0004395	increased cochlear inner hair cell number	"increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi
MP:0004401	increased cochlear outer hair cell number	"increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi
MP:0004409	abnormal neuroepithelium of ampullary crest	"any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
MP:0004413	absent cochlear microphonics	"absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0004417	decreased cochlear nerve compound action potential	"reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0004480	abnormal round window morphology	"any structural anomaly in the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi
MP:0004568	fusion of glossopharyngeal and vagus nerve	"union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004647	decreased lumbar vertebrae number	"reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: 129S5;B6N-Chd7^{tm2a(EUCOMM)Wtsi}/Wtsi
MP:0004718	abnormal vestibular nerve morphology	"any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0004922	abnormal common crus morphology	"any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7⁺ Genetic Background: 129S5;B6N-Chd7^{tm2a(EUCOMM)Wtsi}/Wtsi
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004979	abnormal neuronal precursor cell number	"deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0005106	abnormal incus morphology	"structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0005107	abnormal stapes morphology	"structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Flo Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: C3HeB/FeJ-Chd7^Whi
MP:0005262	coloboma	"anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sod2^tm1Kskk/Sod2^tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2^tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl Allelic Composition: Chd7^tm1.1Dmm/Chd7⁺,Tg(rx3-icre)1Mjam/0 Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgfa^wa1/Tgfa^wa1 Genetic Background: Not Specified Allelic Composition: Chd7^Mt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Lda/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Dz/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Cycn/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Obt/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006280	abnormal digit development	"anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0006305	abnormal optic eminence morphology	"malformation of the embryonic structure that gives rise to the corneal ectoderm" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", UNSW_embryology site:http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0006306	abnormal nasal pit morphology	"malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0006354	abnormal fourth branchial arch artery morphology	"any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1) Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tg(Tbx1-cre)1Joe/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1) Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Fgf8^tm1.2Mrt/Fgf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
MP:0006355	abnormal sixth branchial arch artery morphology	"any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tg(Tbx1-cre)1Joe/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)
MP:0008066	small endolymphatic duct	"reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0008283	small hippocampus	"reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0008547	abnormal neocortex morphology	"any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0009101	clitoris hypoplasia	"underdevelopment or reduced size of the clitoris, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0009944	abnormal olfactory lobe morphology		Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0010526	aortic arch coarctation	"a congenital focal constriction of the aortic arch" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010973	increased periosteum thickness	"increased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Chd7^Gt(XK403)Byg/Chd7^Gt(XK403)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ Allelic Composition: Chd7^Coa1/Chd7^Coa1 Genetic Background: involves: C57BL/6J Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi} Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Chd7^Coa1/Chd7⁺ Genetic Background: involves: C57BL/6J
MP:0011395	decreased fetal cardiomyocyte proliferation	"reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi} Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0011861	increased cranium height	"increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [MGI:mnk]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0012167	abnormal epigenetic regulation of gene expression	"any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]	Show Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi} Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0012703	decreased embryonic neuroepithelium thickness	"reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0012729	abnormal common carotid artery morphology	"any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]	Show Allelic Composition: Chd7^{Gt(RRR136)Byg}/Chd7⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013350	Rathke s pouch hypoplasia	"underdevelopment or reduced size of Rathke s pouch, usually due to a reduced number of cells" [MGI:Anna]	Show Allelic Composition: Clcn1^adr-mto8J/Clcn1^adr-mto8J Genetic Background: B6;C3Fe-Clcn1^adr-mto8J/CxJ
MP:0013466	keratoconjunctivitis sicca	"inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation" [MGI:Anna]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Chd7^Flo/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0013767	decreased palatal rugae number	"reduced number of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [MGI:Anna, PMID:19087265]	Show Allelic Composition: Chd7^Whi/Chd7⁺ Genetic Background: involves: C3HeB/FeJ
MP:0013820	absent optic cup	"absence of the double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [MGI:smb]	Show Allelic Composition: Sod2^tm1Kskk/Sod2^tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2^tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl Allelic Composition: Chd7^tm1.1Dmm/Chd7^tm1.1Dmm,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0030109	abnormal incudomalleolar joint morphology	"any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN
MP:0030340	absent fourth pharyngeal arch artery	"failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna]	Show Allelic Composition: Chd7^Gt(XK403)Byg/Chd7⁺,Tbx1^tm1Bld/Tbx1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
MP:0030402	abnormal stapes head morphology	"any structural anomaly of the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [http://www.biology-online.org/dictionary/Head_of_stapes, https://radiopaedia.org/articles/stapes]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0030405	small stapes obturator foramen	"reduced size of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna]	Show Allelic Composition: Chd7^Ome/Chd7⁺ Genetic Background: involves: BALB/cByJ * C57BL/6J
MP:0030407	abnormal stapes crus morpholgy	"any structural anomaly of either of the two (anterior and posterior) limbs of the stapes that pass from the head to the base or footplate; in mice, the anterior crus is curved and the posterior crus is more straight whereas in humans, the anterior crus is more straight than the posterior crus" [https://medical-dictionary.thefreedictionary.com/anterior+crus+of+stapes, PMID:28117786]	Show Allelic Composition: Chd7^Edy/Chd7⁺ Genetic Background: involves: BALB/c * C3H/HeN

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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