ENSMUSG00000041235


Mus musculus

Features
Gene ID: ENSMUSG00000041235
  
Biological name :Chd7
  
Synonyms : A2AJK6 / Chd7 / Chromodomain-helicase-DNA-binding protein 7
  
Possible biological names infered from orthology : Q9P2D1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 8690406
Gene end: 8867659
  
Corresponding Affymetrix probe sets: 10503161 (MoGene1.0st)   10503166 (MoGene1.0st)   10503168 (MoGene1.0st)   10503170 (MoGene1.0st)   10503172 (MoGene1.0st)   10503174 (MoGene1.0st)   10503176 (MoGene1.0st)   10503178 (MoGene1.0st)   10503180 (MoGene1.0st)   10503182 (MoGene1.0st)   10503184 (MoGene1.0st)   10503186 (MoGene1.0st)   10503188 (MoGene1.0st)   10503190 (MoGene1.0st)   10503192 (MoGene1.0st)   10503194 (MoGene1.0st)   10503196 (MoGene1.0st)   10503198 (MoGene1.0st)   10503200 (MoGene1.0st)   10503202 (MoGene1.0st)   10503204 (MoGene1.0st)   10503206 (MoGene1.0st)   10503208 (MoGene1.0st)   10503210 (MoGene1.0st)   10503212 (MoGene1.0st)   10503214 (MoGene1.0st)   10503216 (MoGene1.0st)   10503218 (MoGene1.0st)   10503220 (MoGene1.0st)   10503222 (MoGene1.0st)   1437745_at (Mouse Genome 430 2.0 Array)   1448026_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043903
Ensembl peptide - ENSMUSP00000152166
Ensembl peptide - ENSMUSP00000127007
Ensembl peptide - ENSMUSP00000123241
Ensembl peptide - ENSMUSP00000118711
Ensembl peptide - ENSMUSP00000059079
NCBI entrez gene - 320790     See in Manteia.
MGI - MGI:2444748
RefSeq - XM_017320263
RefSeq - NM_001277149
RefSeq - XM_006538004
RefSeq - XM_006538005
RefSeq - XM_006538006
RefSeq Peptide - NP_001264078
swissprot - E9PV74
swissprot - A2AJK6
swissprot - A0A1Y7VIV0
swissprot - A0A0R4J1U9
swissprot - A2AJK7
Ensembl - ENSMUSG00000041235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chd7ENSDARG00000075211Danio rerio
 CHD7ENSGALG00000041080Gallus gallus
 CHD7ENSG00000171316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chd9 / Q8BYH8 / Chromodomain-helicase-DNA-binding protein 9 / Q3L8U1*ENSMUSG0000005660848
Chd8 / Q09XV5 / Chromodomain-helicase-DNA-binding protein 8 / Q9HCK8*ENSMUSG0000005375444
Chd6 / A3KFM7 / Chromodomain-helicase-DNA-binding protein 6 / Q8TD26*ENSMUSG0000005713342
Chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSMUSG0000001847417
Chd5 / A2A8L1 / Chromodomain-helicase-DNA-binding protein 5 / Q8TDI0*ENSMUSG0000000504516
Chd4 / Q6PDQ2 / Mus musculus chromodomain helicase DNA binding protein 4 (Chd4), mRNA. / Q14839* / chromodomain helicase DNA binding protein 4*ENSMUSG0000006387016
Chd2 / E9PZM4 / Chromodomain-helicase-DNA-binding protein 2 / O14647*ENSMUSG0000007867115
Chd1 / P40201 / Q9CQS5 / Chromodomain-helicase-DNA-binding protein 1 / O14646*ENSMUSG0000002385214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037259  BRK domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development ISO
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001701 in utero embryonic development ISO
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0003007 heart morphogenesis ISO
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003226 right ventricular compact myocardium morphogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0007417 central nervous system development ISO
 biological_processGO:0007512 adult heart development IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
 biological_processGO:0021545 cranial nerve development ISO
 biological_processGO:0021553 olfactory nerve development IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0030217 T cell differentiation ISO
 biological_processGO:0030540 female genitalia development IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0036302 atrioventricular canal development IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042048 olfactory behavior IMP
 biological_processGO:0042471 ear morphogenesis IMP
 biological_processGO:0042472 inner ear morphogenesis ISO
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043584 nose development ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048752 semicircular canal morphogenesis IGI
 biological_processGO:0048771 tissue remodeling IMP
 biological_processGO:0048806 genitalia development ISO
 biological_processGO:0048844 artery morphogenesis IGI
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050890 cognition ISO
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0060041 retina development in camera-type eye ISO
 biological_processGO:0060123 regulation of growth hormone secretion ISO
 biological_processGO:0060173 limb development ISO
 biological_processGO:0060324 face development ISO
 biological_processGO:0060384 innervation IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 biological_processGO:0060429 epithelium development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0000037 abnormal lateral semicircular canal "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Chd7Mt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Lda/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Dz/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Cycn/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: B6.C3Fe-Chd7Whi

Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000300 thin endocardial cushion "reduced thickness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [J:45302]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0000446 long snout "the anterior facial part of the muzzle having a length greater than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000486 abnormal pulmonary trunk morphology "structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Chd7Mt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Lda/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Dz/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Cycn/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Chd7Mt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Lda/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Dz/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Cycn/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Fgfr3tm1Dor/Fgfr3tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002236 abnormal internal nares morphology "any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0002858 abnormal posterior semicircular canal "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Chd7Mt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Lda/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Dz/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Cycn/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: B6.C3Fe-Chd7Whi

Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld

 MP:0002859 abnormal canal fusion "malformed or mistimed fusion of the canal primordia during development" [J:75619]
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Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003007 ectopic thymus "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: B6.C3Fe-Chd7Whi

Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003162 reduced size of lateral semicircular canal 
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003163 absent posterior semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003164 reduced size of posterior semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0003166 reduced size of superior semicircular canal 
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0003330 abnormal auditory tube "anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0003387 coarctation of aorta "narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003395 abnormal subclavian artery morphology "malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0004290 abnormal stapes footplate "any structural abnormality in the flat portion of the stapes that fits in the oval window" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004310 small otic vesicle "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0004315 absent saccule "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

 MP:0004413 absent cochlear microphonics "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004480 abnormal round window morphology "any structural anomaly in the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0004568 fusion of glossopharyngeal and vagus nerve "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi

 MP:0004718 abnormal vestibular nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+
Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Flo

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Chd7Mt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Lda/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Dz/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Cycn/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Obt/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0006305 abnormal optic eminence morphology "malformation of the embryonic structure that gives rise to the corneal ectoderm" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", UNSW_embryology site:http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0006306 abnormal nasal pit morphology "malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1)

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tg(Tbx1-cre)1Joe/0
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Fgf8tm1.2Mrt/Fgf8+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tg(Tbx1-cre)1Joe/0
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)

 MP:0008066 small endolymphatic duct "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0009101 clitoris hypoplasia "underdevelopment or reduced size of the clitoris, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0009944 abnormal olfactory lobe morphology 
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0010526 aortic arch coarctation "a congenital focal constriction of the aortic arch" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010973 increased periosteum thickness "increased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chd7Gt(XK403)Byg/Chd7Gt(XK403)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

Allelic Composition: Chd7Coa1/Chd7Coa1
Genetic Background: involves: C57BL/6J

Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Chd7Coa1/Chd7+
Genetic Background: involves: C57BL/6J

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011861 increased cranium height "increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [MGI:mnk]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0012729 abnormal common carotid artery morphology "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013350 Rathke s pouch hypoplasia "underdevelopment or reduced size of Rathke s pouch, usually due to a reduced number of cells" [MGI:Anna]
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J
Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ

 MP:0013466 keratoconjunctivitis sicca "inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation" [MGI:Anna]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0013767 decreased palatal rugae number "reduced number of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [MGI:Anna, PMID:19087265]
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Allelic Composition: Chd7Whi/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0013820 absent optic cup "absence of the double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [MGI:smb]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030109 abnormal incudomalleolar joint morphology "any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0030340 absent fourth pharyngeal arch artery "failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

 MP:0030402 abnormal stapes head morphology "any structural anomaly of the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [http://www.biology-online.org/dictionary/Head_of_stapes, https://radiopaedia.org/articles/stapes]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0030405 small stapes obturator foramen "reduced size of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna]
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Allelic Composition: Chd7Ome/Chd7+
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0030407 abnormal stapes crus morpholgy "any structural anomaly of either of the two (anterior and posterior) limbs of the stapes that pass from the head to the base or footplate; in mice, the anterior crus is curved and the posterior crus is more straight whereas in humans, the anterior crus is more straight than the posterior crus" [https://medical-dictionary.thefreedictionary.com/anterior+crus+of+stapes, PMID:28117786]
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Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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