MP:0000029 | abnormal malleus morphology | "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0000031 | abnormal cochlea morphology | "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0000034 | abnormal vestibule morphology | "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0000037 | abnormal lateral semicircular canal | "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tgfawa1/Tgfawa1 Genetic Background: Not Specified
Allelic Composition: Chd7Mt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Lda/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Dz/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Cycn/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: B6.C3Fe-Chd7Whi
Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld
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MP:0000049 | abnormal middle ear morphology | "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0000300 | thin endocardial cushion | "reduced thickness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [J:45302] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0000446 | long snout | "the anterior facial part of the muzzle having a length greater than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0000486 | abnormal pulmonary trunk morphology | "structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000787 | abnormal telencephalon morphology | "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000794 | abnormal parietal lobe morphology | "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000798 | abnormal frontal lobe morphology | "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000809 | absent hippocampus | "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000827 | dilated third ventricle | "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
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MP:0001056 | abnormal cranial nerve morphology | "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001074 | abnormal vagus nerve morphology | "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Tgfawa1/Tgfawa1 Genetic Background: Not Specified
Allelic Composition: Chd7Mt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Lda/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Dz/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Cycn/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
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MP:0001300 | ocular hypertelorism | "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0001306 | small lens | "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0 Genetic Background: involves: 129S6/SvEvTac * FVB
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MP:0001337 | dry eyes | "absence of natural or normal moisture in the eye" [J:53284] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0001386 | abnormal maternal nurturing | "failure of mothers to tend offspring" [J:39801] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
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MP:0001388 | abnormal stationary movement | "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thpotm1Mwm/Thpo+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Tgfawa1/Tgfawa1 Genetic Background: Not Specified
Allelic Composition: Chd7Mt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Lda/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Dz/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Cycn/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0001395 | bi-directional circling | "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Fgfr3tm1Dor/Fgfr3tm1Dor Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi
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MP:0001410 | head bobbing | "compulsive up and down movement of the head" [J:17123] |
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Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thpotm1Mwm/Thpo+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001522 | impaired swimming | "reduced ability or inability to swim" [J:45446, J:39081] |
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Allelic Composition: Thpotm1Mwm/Thpo+ Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Thpotm1Mwm/Thpo+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001526 | abnormal placing response | "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml] |
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Allelic Composition: Thpotm1Mwm/Thpo+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Rpe65450L/Rpe65450L Genetic Background: BALB/c
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MP:0001850 | otitis media | "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0002177 | abnormal outer ear morphology | "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002236 | abnormal internal nares morphology | "any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002428 | abnormal semicircular canal | "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7tm1.2Dmm/Chd7tm1.2Dmm Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
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MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002730 | head shaking | "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0002741 | small olfactory bulb | "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0002858 | abnormal posterior semicircular canal | "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tgfawa1/Tgfawa1 Genetic Background: Not Specified
Allelic Composition: Chd7Mt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Lda/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Dz/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Cycn/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: B6.C3Fe-Chd7Whi
Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld
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MP:0002859 | abnormal canal fusion | "malformed or mistimed fusion of the canal primordia during development" [J:75619] |
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Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0002950 | abnormal neural crest cell migration | "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003007 | ectopic thymus | "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
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MP:0003069 | abnormal superior semicircular canal | "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
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MP:0003126 | abnormal vulva morphology | "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0003148 | reduced cochlear coiling | "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0003161 | absent lateral semicircular canal | |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: B6.C3Fe-Chd7Whi
Allelic Composition: Chd7Whi/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: B6.Cg-Chd7Whi Tbx1tm1Bld
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0003162 | reduced size of lateral semicircular canal | |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0003163 | absent posterior semicircular canal | |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0003164 | reduced size of posterior semicircular canal | |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
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MP:0003166 | reduced size of superior semicircular canal | |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0003330 | abnormal auditory tube | "anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0003387 | coarctation of aorta | "narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003395 | abnormal subclavian artery morphology | "malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
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MP:0003451 | absent olfactory bulb | "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0003703 | abnormal vestibulocochlear ganglion morphology | "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0003938 | abnormal ear development | "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7tm1.1Dmm/Chd7+,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
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MP:0004188 | delayed embryo turning | "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
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MP:0004249 | abnormal crista ampullaris morphology | "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0004269 | abnormal optic cup morphology | "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
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MP:0004290 | abnormal stapes footplate | "any structural abnormality in the flat portion of the stapes that fits in the oval window" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0004310 | small otic vesicle | "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0004315 | absent saccule | "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0004369 | absent utricle | "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0004395 | increased cochlear inner hair cell number | "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
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MP:0004401 | increased cochlear outer hair cell number | "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
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MP:0004409 | abnormal neuroepithelium of ampullary crest | "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
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MP:0004413 | absent cochlear microphonics | "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0004417 | decreased cochlear nerve compound action potential | "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0004480 | abnormal round window morphology | "any structural anomaly in the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
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MP:0004568 | fusion of glossopharyngeal and vagus nerve | "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004647 | decreased lumbar vertebrae number | "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi
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MP:0004718 | abnormal vestibular nerve morphology | "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
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MP:0004736 | abnormal distortion product otoacoustic emission | "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0004922 | abnormal common crus morphology | "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J)
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7+ Genetic Background: 129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi
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MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004979 | abnormal neuronal precursor cell number | "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0005106 | abnormal incus morphology | "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0005107 | abnormal stapes morphology | "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Flo
Allelic Composition: Chd7Whi/Chd7+ Genetic Background: C3HeB/FeJ-Chd7Whi
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MP:0005262 | coloboma | "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0 Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
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MP:0005307 | head tossing | "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgfawa1/Tgfawa1 Genetic Background: Not Specified
Allelic Composition: Chd7Mt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Lda/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Dz/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Cycn/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Obt/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0005545 | abnormal lens development | "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
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MP:0006030 | abnormal otic vesicle formation | "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0006280 | abnormal digit development | "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0006305 | abnormal optic eminence morphology | "malformation of the embryonic structure that gives rise to the corneal ectoderm" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", UNSW_embryology site:http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0006306 | abnormal nasal pit morphology | "malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0006354 | abnormal fourth branchial arch artery morphology | "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1)
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tg(Tbx1-cre)1Joe/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Fgf8tm1.2Mrt/Fgf8+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
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MP:0006355 | abnormal sixth branchial arch artery morphology | "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tg(Tbx1-cre)1Joe/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)
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MP:0008066 | small endolymphatic duct | "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0008283 | small hippocampus | "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0008547 | abnormal neocortex morphology | "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0009101 | clitoris hypoplasia | "underdevelopment or reduced size of the clitoris, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0009655 | abnormal secondary palate development | "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0009890 | cleft secondary palate | "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0009944 | abnormal olfactory lobe morphology | |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0010526 | aortic arch coarctation | "a congenital focal constriction of the aortic arch" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010973 | increased periosteum thickness | "increased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * C57BL/6 * Swiss Webster
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MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Chd7Gt(XK403)Byg/Chd7Gt(XK403)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
Allelic Composition: Chd7Coa1/Chd7Coa1 Genetic Background: involves: C57BL/6J
Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Chd7Coa1/Chd7+ Genetic Background: involves: C57BL/6J
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MP:0011395 | decreased fetal cardiomyocyte proliferation | "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0011861 | increased cranium height | "increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [MGI:mnk] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0012167 | abnormal epigenetic regulation of gene expression | "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029] |
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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MP:0012703 | decreased embryonic neuroepithelium thickness | "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0012729 | abnormal common carotid artery morphology | "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna] |
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Allelic Composition: Chd7Gt(RRR136)Byg/Chd7+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0013350 | Rathke s pouch hypoplasia | "underdevelopment or reduced size of Rathke s pouch, usually due to a reduced number of cells" [MGI:Anna] |
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Allelic Composition: Clcn1adr-mto8J/Clcn1adr-mto8J Genetic Background: B6;C3Fe-Clcn1adr-mto8J/CxJ
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MP:0013466 | keratoconjunctivitis sicca | "inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation" [MGI:Anna] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Chd7Flo/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0013767 | decreased palatal rugae number | "reduced number of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [MGI:Anna, PMID:19087265] |
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Allelic Composition: Chd7Whi/Chd7+ Genetic Background: involves: C3HeB/FeJ
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MP:0013820 | absent optic cup | "absence of the double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [MGI:smb] |
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0 Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl
Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
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MP:0030109 | abnormal incudomalleolar joint morphology | "any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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MP:0030340 | absent fourth pharyngeal arch artery | "failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Tbx1tm1Bld/Tbx1+ Genetic Background: either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
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MP:0030402 | abnormal stapes head morphology | "any structural anomaly of the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [http://www.biology-online.org/dictionary/Head_of_stapes, https://radiopaedia.org/articles/stapes] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0030405 | small stapes obturator foramen | "reduced size of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna] |
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Allelic Composition: Chd7Ome/Chd7+ Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0030407 | abnormal stapes crus morpholgy | "any structural anomaly of either of the two (anterior and posterior) limbs of the stapes that pass from the head to the base or footplate; in mice, the anterior crus is curved and the posterior crus is more straight whereas in humans, the anterior crus is more straight than the posterior crus" [https://medical-dictionary.thefreedictionary.com/anterior+crus+of+stapes, PMID:28117786] |
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Allelic Composition: Chd7Edy/Chd7+ Genetic Background: involves: BALB/c * C3H/HeN
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