ENSDARG00000075211


Danio rerio

Features
Gene ID: ENSDARG00000075211
  
Biological name :chd7
  
Synonyms : chd7 / chromodomain helicase DNA binding protein 7
  
Possible biological names infered from orthology : A2AJK6 / Q9P2D1
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 21765670
Gene end: 21820697
  
Corresponding Affymetrix probe sets: Dr.18319.2.A1_at (Zebrafish Array)   Dr.6240.1.A1_at (Zebrafish Array)   XM_692864_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108570
Ensembl peptide - ENSDARP00000114372
Ensembl peptide - ENSDARP00000011638
NCBI entrez gene - 569471     See in Manteia.
RefSeq - XM_692864
swissprot - E7F766
swissprot - F1QGL1
swissprot - F1QQ92
ZFIN ID - ZDB-GENE-070912-179
Ensembl - ENSDARG00000075211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHD7ENSGALG00000041080Gallus gallus
 CHD7ENSG00000171316Homo sapiens
 Chd7ENSMUSG00000041235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chd6 / chromodomain helicase DNA binding protein 6 / Q8TD26*ENSDARG0000001724439
chd9 / chromodomain helicase DNA binding protein 9 / Q3L8U1* / Q8BYH8*ENSDARG0000007449839
chd8 / chromodomain helicase DNA binding protein 8 / Q09XV5* / Q9HCK8*ENSDARG0000007554335
chd5 / chromodomain helicase DNA binding protein 5 / A2A8L1* / Q8TDI0*ENSDARG0000010508316
chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSDARG0000002140515
chd4b / chromodomain helicase DNA binding protein 4b / CHD4* / Q14839* / Q6PDQ2* / chromodomain helicase DNA binding protein 4* / Mus musculus chromodomain helicase DNA binding protein 4 (C...ENSDARG0000002578915
chd4a / chromodomain helicase DNA binding protein 4a / CHD4* / Q14839* / Q6PDQ2* / chromodomain helicase DNA binding protein 4* / Mus musculus chromodomain helicase DNA binding protein 4 (C...ENSDARG0000006353515
chd2 / chromodomain helicase DNA binding protein 2 / E9PZM4* / O14647* / AC013394.1*ENSDARG0000006068714
chd1 / chromodomain helicase DNA binding protein 1 / O14646* / P40201* / Q9CQS5*ENSDARG0000010378713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009303 rRNA transcription IGI
 biological_processGO:0014029 neural crest formation IMP
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048798 swim bladder inflation IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060319 primitive erythrocyte differentiation IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain glial cell (sensu Vertebrata) decreased amount , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer disorganized , abnormal
Show

 ZFA:0000045 neural crest neural crest melanoblast increased amount , abnormal
neural crest increased amount , abnormal
neural crest spatial pattern , abnormal
neural crest melanoblast decreased amount , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle lacks parts or has fewer parts of type otolith , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye morphology , abnormal
eye iridophore absent , abnormal
Show

 ZFA:0000114 heart heart tubular , abnormal
heart morphology , abnormal
heart increased size , abnormal
heart edematous , abnormal
Show

 ZFA:0000131 neural keel neural keel decreased amount , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer aplastic , abnormal
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 ZFA:0000152 retina retina malformed , abnormal
Show

 ZFA:0000155 somite somite increased amount , abnormal
Show

 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus has fewer parts of type motor neuron , abnormal
Show

 ZFA:0000217 inner ear inner ear morphology , abnormal
inner ear has fewer parts of type otolith , abnormal
Show

 ZFA:0000243 neuromast neuromast absent , abnormal
neuromast decreased amount , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion axon decreased length , abnormal
trigeminal ganglion axon decreased amount , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal malformed , abnormal
Show

 ZFA:0000471 atrium atrium orientation cardiac ventricle , abnormal
Show

 ZFA:0000641 cranial nerve cranial nerve motor neuron position , abnormal
cranial nerve motor neuron disorganized , abnormal
Show

 ZFA:0000737 cranium cranium glial cell absent , abnormal
cranium glial cell (sensu Vertebrata) absent , abnormal
Show

 ZFA:0000818 vagal neural crest vagal neural crest decreased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved , abnormal
whole organism anterior-posterior axis kinked , abnormal
whole organism balance , abnormal
whole organism circling , abnormal
whole organism increased amount , abnormal
whole organism decreased pigmentation , abnormal
whole organism Melanin decreased amount , abnormal
whole organism melanocyte shape , abnormal
Show

 ZFA:0001114 head head flattened , abnormal
head neuroblast decreased amount , abnormal
head decreased size , abnormal
head melanoblast increased amount , abnormal
head melanoblast decreased amount , abnormal
Show

 ZFA:0001115 trunk trunk anterior-posterior axis curved , abnormal
trunk iridophore absent , abnormal
trunk spatial pattern , abnormal
Show

 ZFA:0001117 post-vent region post-vent region truncated , abnormal
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 ZFA:0001161 pectoral fin pectoral fin hypoplastic , abnormal
Show

 ZFA:0001189 vertebra vertebra shape , abnormal
vertebra increased distance vertebra , abnormal
vertebra decreased size , abnormal
vertebra has fewer parts of type neural spine , abnormal
vertebra has fewer parts of type hemal spine , abnormal
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 ZFA:0001194 cranial neural crest cranial neural crest disorganized , abnormal
cranial neural crest has fewer parts of type cranial neural crest cell , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage absent , abnormal
Meckels cartilage morphology , ameliorated
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch absent , abnormal
ventral mandibular arch morphology , ameliorated
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel irregular spatial pattern , abnormal
Show

 ZFA:0001291 facial ganglion facial ganglion hypoplastic , abnormal
facial ganglion axon decreased length , abnormal
facial ganglion axon decreased amount , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch malformed , abnormal
pharyngeal arch decreased amount , abnormal
pharyngeal arch chondrocyte absent , abnormal
pharyngeal arch neural crest cell decreased amount , abnormal
Show

 ZFA:0001336 neural spine neural spine decreased size , abnormal
Show

 ZFA:0001364 hemal spine hemal spine decreased size , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
ceratohyal cartilage absent , abnormal
ceratohyal cartilage morphology , ameliorated
Show

 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
pharyngeal arch cartilage morphology , ameliorated
Show

 ZFA:0001462 somite border somite border malformed , abnormal
Show

 ZFA:0001469 lateral line lateral line glial cell decreased amount , abnormal
lateral line glial cell (sensu Vertebrata) increased amount , abnormal
lateral line glial cell (sensu Vertebrata) morphology , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
ceratobranchial cartilage morphology , ameliorated
Show

 ZFA:0001527 epibranchial cartilage epibranchial cartilage neuroblast decreased amount , abnormal
Show

 ZFA:0001580 neurocranium neurocranium decreased size , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 absent , abnormal
Show

 ZFA:0001617 otolith otolith shape , abnormal
otolith increased size , abnormal
otolith increased variability of size , abnormal
otolith morphology , abnormal
otolith amount , abnormal
otolith decreased size , abnormal
otolith fused with otolith , abnormal
Show

 ZFA:0001634 perichondrium perichondrium disorganized , abnormal
perichondrium decreased amount , abnormal
Show

 ZFA:0005730 cranial motor neuron cranial motor neuron decreased amount , abnormal
Show

 ZFA:0005775 enteric neuron enteric neuron decreased amount , abnormal
Show

 ZFA:0007082 neural plate border neural plate border decreased amount , abnormal
Show

 ZFA:0007085 migratory neural crest migratory neural crest mislocalised , abnormal
Show

 ZFA:0009052 motor neuron motor neuron decreased amount , abnormal
Show

 ZFA:0009053 sensory neuron sensory neuron decreased amount , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
Show

 ZFA:0009125 olfactory receptor cell olfactory receptor cell decreased amount , abnormal
Show

 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell decreased distribution , abnormal
myelinating Schwann cell decreased amount , abnormal
myelinating Schwann cell myelination disrupted , abnormal
myelinating Schwann cell increased amount , abnormal
myelinating Schwann cell position , ameliorated
myelinating Schwann cell myelination process quality , ameliorated
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell absent , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
Show

 ZFA:0009359 microvillous olfactory receptor neuron microvillous olfactory receptor neuron disorganized , abnormal
microvillous olfactory receptor neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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