ENSG00000189298


Homo sapiens

Features
Gene ID: ENSG00000189298
  
Biological name :ZKSCAN3
  
Synonyms : Q9BRR0 / zinc finger with KRAB and SCAN domains 3 / ZKSCAN3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.1
Gene start: 28349914
Gene end: 28369177
  
Corresponding Affymetrix probe sets: 1562303_at (Human Genome U133 Plus 2.0 Array)   1562305_x_at (Human Genome U133 Plus 2.0 Array)   211773_s_at (Human Genome U133 Plus 2.0 Array)   235840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000252211
Ensembl peptide - ENSP00000341883
Ensembl peptide - ENSP00000366465
NCBI entrez gene - 80317     See in Manteia.
OMIM - 612791
RefSeq - XM_017011320
RefSeq - NM_001242894
RefSeq - NM_001242895
RefSeq - NM_024493
RefSeq - XM_005249423
RefSeq - XM_006715215
RefSeq - XM_006715216
RefSeq - XM_006715218
RefSeq Peptide - NP_001229824
RefSeq Peptide - NP_077819
RefSeq Peptide - NP_001229823
swissprot - Q9BRR0
Ensembl - ENSG00000189298
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Zkscan3ENSMUSG00000021327Mus musculus
 Zkscan4ENSMUSG00000054931Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q969J2 / ZKSCAN4 / zinc finger with KRAB and SCAN domains 4ENSG0000018762685
Q15776 / ZKSCAN8 / zinc finger with KRAB and SCAN domains 8ENSG0000019831545
P17029 / ZKSCAN1 / zinc finger with KRAB and SCAN domains 1ENSG0000010626143
O43309 / ZSCAN12 / zinc finger and SCAN domain containing 12ENSG0000015869141
Q9Y5A6 / ZSCAN21 / zinc finger and SCAN domain containing 21ENSG0000016652940
Q86W11 / ZSCAN30 / zinc finger and SCAN domain containing 30ENSG0000018681439
P49910 / ZNF165 / zinc finger protein 165ENSG0000019727937
P10073 / ZSCAN22 / zinc finger and SCAN domain containing 22ENSG0000018231836
Q9UNY5 / ZNF232 / zinc finger protein 232ENSG0000016784035
Q16670 / ZSCAN26 / zinc finger and SCAN domain containing 26ENSG0000019706235
Q96LW9 / ZSCAN31 / zinc finger and SCAN domain containing 31ENSG0000023510934
O15535 / ZSCAN9 / zinc finger and SCAN domain containing 9ENSG0000013718534
Q8NF99 / ZNF397 / zinc finger protein 397ENSG0000018681233
Q9H4T2 / ZSCAN16 / zinc finger and SCAN domain containing 16ENSG0000019681232
Q3MJ62 / ZSCAN23 / zinc finger and SCAN domain containing 23ENSG0000018798731
ZNF24 / P17028 / zinc finger protein 24ENSG0000017246630
Q96N95 / ZNF396 / zinc finger protein 396ENSG0000018649626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001909  Krueppel-associated box
 IPR003309  SCAN domain
 IPR008916  Retrovirus capsid, C-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036051  KRAB domain superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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