ENSGALG00000004285


Gallus gallus

Features
Gene ID: ENSGALG00000004285
  
Biological name :HNF4A
  
Synonyms : hepatocyte nuclear factor 4-alpha / HNF4A
  
Possible biological names infered from orthology : P41235 / P49698
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 5564388
Gene end: 5578996
  
Corresponding Affymetrix probe sets: Gga.19277.1.S1_at (Chicken Array)   GgaAffx.26151.1.S1_at (Chicken Array)   GgaAffx.2648.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006799
NCBI entrez gene - 419198     See in Manteia.
RefSeq - NM_001030855
RefSeq - XM_015296366
RefSeq Peptide - NP_001026026
swissprot - F1NZ15
Ensembl - ENSGALG00000004285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnf4aENSDARG00000021494Danio rerio
 HNF4AENSG00000101076Homo sapiens
 Hnf4aENSMUSG00000017950Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HNF4G / hepatocyte nuclear factor 4 gamma / Q14541*ENSGALG0000004262172
HNF4beta / hepatic nuclear factor 4beta ENSGALG0000000570867
RXRG / retinoic acid receptor RXR-gamma / P28705* / P48443* / retinoid X receptor gamma*ENSGALG0000004073031
NR2F6 / nuclear receptor subfamily 2 group F member 6 / P10588* / P43136*ENSGALG0000004301030
NR2F1 / nuclear receptor subfamily 2 group F member 1 / P10589*ENSGALG0000002790729
NR2F2 / COUP transcription factor 2 / P24468* / P43135* / nuclear receptor subfamily 2 group F member 2*ENSGALG0000000700029
NR2E1 / nuclear receptor subfamily 2 group E member 1 / Q64104* / Q9Y466*ENSGALG0000001530526
NR2E3 / photoreceptor-specific nuclear receptor / Q9QXZ7* / Q9Y5X4* / nuclear receptor subfamily 2 group E member 3*ENSGALG0000000209325
NR2C2 / nuclear receptor subfamily 2 group C member 2 / P49116* / P49117*ENSGALG0000000851925
NR2C1 / nuclear receptor subfamily 2 group C member 1 / P13056* / Q505F1*ENSGALG0000001132724
RXRA / retinoid X receptor alpha / P19793* / P28700*ENSGALG0000004205514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003068  Transcription factor COUP
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006591 ornithine metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010470 regulation of gastrulation IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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