ENSMUSG00000001656


Mus musculus

Features
Gene ID: ENSMUSG00000001656
  
Biological name :Hoxc11
  
Synonyms : Homeobox protein Hox-C11 / Hoxc11 / P31313
  
Possible biological names infered from orthology : homeobox C11 / O43248
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102954427
Gene end: 102957708
  
Corresponding Affymetrix probe sets: 10427277 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000001701
NCBI entrez gene - 109663     See in Manteia.
MGI - MGI:96193
RefSeq - NM_001024842
RefSeq Peptide - NP_001020013
swissprot - P31313
Ensembl - ENSMUSG00000001656
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc11bENSDARG00000102631Danio rerio
 Q58EL0ENSDARG00000070351Danio rerio
 HOXC11ENSGALG00000042416Gallus gallus
 HOXC11ENSG00000123388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821053
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249947
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334223
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822723
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093822
Hoxd10 / P28359 / Homeobox protein Hox-D10 / P28358* / homeobox D10*ENSMUSG0000005036822
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613921
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820321
Hoxc10 / P31257 / Homeobox protein Hox-C10 / Q9NYD6* / homeobox C10*ENSMUSG0000002248421
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032820
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087520
Hoxd12 / P23812 / Homeobox protein Hox-D12 / P35452* / homeobox D12*ENSMUSG0000000182320
Hoxc13 / P50207 / Homeobox protein Hox-C13 / P31276* / homeobox C13*ENSMUSG0000000165519
Hoxb13 / P70321 / Homeobox protein Hox-B13 / Q92826* / homeobox B13*ENSMUSG0000004960418
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR021918  Domain of unknown function DUF3528, homeobox protein, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0001656 metanephros development IGI
 biological_processGO:0001759 organ induction IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hoxa11tm1Dmwe/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hoxa11tm1Dmwe/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Dmwe/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003600 ectopic kidney 
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003604 single kidney 
Show

Allelic Composition: Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003855 abnormal forelimb zeugopod morphology 
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003857 abnormal hindlimb zeugopod morphology 
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004656 absent sacral vertebrae "absence of all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11+,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: Hoxa11tm1Mrc/Hoxa11tm1Mrc,Hoxc11tm1Mrc/Hoxc11tm1Mrc,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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