ENSMUSG00000049604


Mus musculus

Features
Gene ID: ENSMUSG00000049604
  
Biological name :Hoxb13
  
Synonyms : Homeobox protein Hox-B13 / Hoxb13 / P70321
  
Possible biological names infered from orthology : homeobox B13 / Q92826
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96194316
Gene end: 96197447
  
Corresponding Affymetrix probe sets: 10380614 (MoGene1.0st)   1419576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056315
NCBI entrez gene - 15408     See in Manteia.
MGI - MGI:107730
RefSeq - NM_008267
RefSeq Peptide - NP_032293
swissprot - P70321
Ensembl - ENSMUSG00000049604
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXB13ENSGALG00000033154Gallus gallus
 HOXB13ENSG00000159184Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820352
Hoxc13 / P50207 / Homeobox protein Hox-C13 / P31276* / homeobox C13*ENSMUSG0000000165548
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181943
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032821
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249921
Hoxc10 / P31257 / Homeobox protein Hox-C10 / Q9NYD6* / homeobox C10*ENSMUSG0000002248421
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822720
Hoxc11 / P31313 / Homeobox protein Hox-C11 / O43248* / homeobox C11*ENSMUSG0000000165620
Hoxd12 / P23812 / Homeobox protein Hox-D12 / P35452* / homeobox D12*ENSMUSG0000000182320
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093820
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613919
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087518
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821018
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334218
Hoxd10 / P28359 / Homeobox protein Hox-D10 / P28358* / homeobox D10*ENSMUSG0000005036817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR022067  Homeobox protein Hox1A3 N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0040008 regulation of growth IMP
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IGI
 biological_processGO:0060743 epithelial cell maturation involved in prostate gland development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000588 thick tail "a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0000778 abnormal tract 
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0002809 enlarged spinal cord size "larger appearance of the spinal cord" [J:83935]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

 MP:0009380 abnormal ventral prostate morphology 
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc,Hoxd13tm1Mrc/Hoxd13tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb13tm2Mrc/Hoxb13tm2Mrc,Hoxd13tm1Mrc/Hoxd13tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

Allelic Composition: Hoxb13tm1Mrc/Hoxb13tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm3Mrc/Hoxb13tm3Mrc
Genetic Background: Not Specified

Allelic Composition: Hoxb13tm4Mrc/Hoxb13tm4Mrc
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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