ENSMUSG00000001823


Mus musculus

Features
Gene ID: ENSMUSG00000001823
  
Biological name :Hoxd12
  
Synonyms : Homeobox protein Hox-D12 / Hoxd12 / P23812
  
Possible biological names infered from orthology : homeobox D12 / P35452
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 74675013
Gene end: 74677705
  
Corresponding Affymetrix probe sets: 10472949 (MoGene1.0st)   1450553_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001878
NCBI entrez gene - 15432     See in Manteia.
MGI - MGI:96204
RefSeq - NM_008274
RefSeq Peptide - NP_032300
swissprot - P23812
Ensembl - ENSMUSG00000001823
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90471ENSDARG00000059263Danio rerio
 HOXD12ENSGALG00000009274Gallus gallus
 HOXD12ENSG00000170178Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032845
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093825
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821025
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334225
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249925
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820324
Hoxc11 / P31313 / Homeobox protein Hox-C11 / O43248* / homeobox C11*ENSMUSG0000000165623
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087522
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613922
Hoxc10 / P31257 / Homeobox protein Hox-C10 / Q9NYD6* / homeobox C10*ENSMUSG0000002248422
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822722
Hoxb13 / P70321 / Homeobox protein Hox-B13 / Q92826* / homeobox B13*ENSMUSG0000004960421
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181921
Hoxd10 / P28359 / Homeobox protein Hox-D10 / P28358* / homeobox D10*ENSMUSG0000005036820
Hoxc13 / P50207 / Homeobox protein Hox-C13 / P31276* / homeobox C13*ENSMUSG0000000165520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Hoxd12tm1Mrc/Hoxd12tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Hoxd12tm1Mrc/Hoxd12+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxd12tm2Ddu/Hoxd12tm2Ddu,Hoxd13tm2Ddu/Hoxd13tm2Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd12tm2Ddu/Hoxd12tm2Ddu,Hoxd13tm2Ddu/Hoxd13tm2Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Hoxd12tm2Ddu/Hoxd12tm2Ddu,Hoxd13tm2Ddu/Hoxd13tm2Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kittm1Bsm/Kittm1Bsm
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hoxd12tm1Mrc/Hoxd12+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxd12tm2Ddu/Hoxd12tm2Ddu,Hoxd13tm2Ddu/Hoxd13tm2Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kittm1Bsm/Kittm1Bsm
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hoxd12tm1Mrc/Hoxd12tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Hoxd12tm2Ddu/Hoxd12+,Hoxd13tm1Ddu/Hoxd13+
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Hoxd12tm2Ddu/Hoxd12tm2Ddu,Hoxd13tm2Ddu/Hoxd13tm2Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxd12tm1Mrc/Hoxd12tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu,Hoxd12tm2Ddu/Hoxd12tm2Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0006253 clinodactyly "abnormal lateral curvature of one or more digits towards or away from each other" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:98519]
Show

Allelic Composition: Hoxd12m1Hsj/Hoxd12m1Hsj
Genetic Background: involves: BALB/cJ

 MP:0009055 abnormal internal anal sphincter morphology "any structural abnormality of the smooth muscle ring, formed by an increase of the circular muscle fibers of the rectum, situated at the upper end of the anal canal, internal to the outer voluntary external anal sphincter" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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