ENSMUSG00000022484


Mus musculus

Features
Gene ID: ENSMUSG00000022484
  
Biological name :Hoxc10
  
Synonyms : Homeobox protein Hox-C10 / Hoxc10 / P31257
  
Possible biological names infered from orthology : homeobox C10 / Q9NYD6
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102966796
Gene end: 102971893
  
Corresponding Affymetrix probe sets: 10427280 (MoGene1.0st)   1439798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001699
NCBI entrez gene - 209448     See in Manteia.
MGI - MGI:96192
RefSeq - NM_010462
RefSeq Peptide - NP_034592
swissprot - P31257
Ensembl - ENSMUSG00000022484
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc10aENSDARG00000070348Danio rerio
 HOXC10ENSGALG00000029393Gallus gallus
 HOXC10ENSG00000180818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxd10 / P28359 / Homeobox protein Hox-D10 / P28358* / homeobox D10*ENSMUSG0000005036844
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093843
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334226
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822726
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613924
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087524
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032820
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249920
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821019
Hoxc13 / P50207 / Homeobox protein Hox-C13 / P31276* / homeobox C13*ENSMUSG0000000165519
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820319
Hoxc11 / P31313 / Homeobox protein Hox-C11 / O43248* / homeobox C11*ENSMUSG0000000165619
Hoxb13 / P70321 / Homeobox protein Hox-B13 / Q92826* / homeobox B13*ENSMUSG0000004960418
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181917
Hoxd12 / P23812 / Homeobox protein Hox-D12 / P35452* / homeobox D12*ENSMUSG0000000182317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IGI
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050905 neuromuscular process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003604 single kidney 
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003854 abnormal forelimb stylopod morphology 
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003856 abnormal hindlimb stylopod morphology 
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004614 caudal vertebral transformation "homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004627 abnormal trochanter morphology "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004654 absent lumbar vertebrae "absence of all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004694 absent patella "absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005504 abnormal ligament morphology "structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
Show

Allelic Composition: Ssbp2tm1Lana/Ssbp2tm1Lana,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6

 MP:0006429 abnormal hyaline cartilage morphology "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010240 decreased skeletal muscle size "less than average dimensions of one or more of the muscles of the skeleton" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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