| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0000381 | enlarged hair follicles | "increased size of the epidermal invaginations from which the hair shaft develops" [J:30249] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000652 | enlarged sebaceous gland | "increased size of the sebum secreting glands of the hair shaft" [J:30249] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0000659 | prostate gland hyperplasia | "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
Show
Allelic Composition: Klf5tm1.1Jtd/Klf5tm1.1Jtd
Genetic Background: involves: C57BL/6
Allelic Composition: Klf5tm1.1Jtd/Klf5+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2
|
| MP:0001163 | abnormal coagulating gland | "malformed or malfunctioning anterior lobe of the prostate" [J:64981] |
Show
Allelic Composition: Klf5tm1.1Jtd/Klf5tm1.1Jtd
Genetic Background: involves: C57BL/6
|
| MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001303 | abnormal lens morphology | "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001306 | small lens | "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001312 | abnormal cornea morphology | "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001314 | corneal opacity | "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001320 | small pupils | "smaller than normal size of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001322 | abnormal iris morphology | "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001340 | abnormal eyelid morphology | "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001346 | abnormal lacrimal gland morphology | "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv
|
| MP:0001728 | failure of implantation | "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772] |
Show
Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Klf5tm1.1Jtd/Klf5tm1.1Jtd
Genetic Background: involves: C57BL/6
|
| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002274 | abnormal type I pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002275 | abnormal type II pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002579 | disorganized secondary lens fibers | "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0002663 | failure to form blastocele | "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904] |
Show
Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klf5tm1.1Jwel/Klf5tm1.1Jwel
Genetic Background: Not Specified
|
| MP:0002718 | abnormal inner cell mass | "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv
|
| MP:0003092 | reduced corneal stroma thickness | "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv
|
| MP:0003237 | abnormal lens epithelium morphology | "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klf5tm1.1Jtd/Klf5tm1.1Jtd
Genetic Background: involves: C57BL/6
Allelic Composition: Klf5tm1.1Jtd/Klf5+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2
|
| MP:0003671 | abnormal eyelid opening | |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0003694 | failure to hatch from the zona pellucida | "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klf5tm1.1Jwel/Klf5tm1.1Jwel
Genetic Background: Not Specified
|
| MP:0003828 | pulmonary edema | "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0004481 | abnormal conjunctival epithelium | "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB
|
| MP:0004484 | altered response of heart to induced stress | "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0004486 | decreased response of heart to induced stress | "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv
|
| MP:0004780 | abnormal surfactant secretion | "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004883 | abnormal blood vessel healing | "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004962 | decreased prostate weight | "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Klf5tm1.1Jtd/Klf5tm1.1Jtd
Genetic Background: involves: C57BL/6
Allelic Composition: Klf5tm1.1Jtd/Klf5+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2
|
| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005028 | abnormal trophectoderm | "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761] |
Show
Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005176 | eyelids fail to open | "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0005247 | abnormal extraocular muscle morphology | "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferrior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0005287 | narrow eye opening | "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0005300 | abnormal corneal stroma morphology | "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0005573 | increased breathing frequency | "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0005595 | abnormal vascular smooth muscle physiology | "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB
|
| MP:0006167 | eyelid edema | "an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0008880 | lacrimal gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0009381 | abnormal dorsolateral prostate morphology | |
Show
Allelic Composition: Klf5tm1.1Jtd/Klf5+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2
|
| MP:0009742 | increased corneal stroma thickness | "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0009866 | abnormal aorta wall morphology | "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0009935 | abnormal meibomian gland acinus morphology | "anomalies of the sac-like structures comprising the sebaceous glands located at the rim of the eyelids and responsible for producing sebum" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
|
| MP:0010018 | lung vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0010579 | increased heart left ventricle size | "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0010814 | absent alveolar lamellar bodies | "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0010816 | decreased type I pneumocyte number | "reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144] |
Show
Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0010825 | abnormal lung saccule morphology | "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0010894 | pulmonary alveolar edema | "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011093 | complete embryonic lethality at implantation | "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith] |
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Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klf5tm1.1Jwel/Klf5tm1.1Jwel
Genetic Background: Not Specified
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| MP:0011143 | thick lung-associated mesenchyme | "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna] |
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011163 | increased wet-to-dry lung weight ratio | "an increase in the ratio of wet lung weight (measured immediately after lung excision) to oven-dried lung weight relative to control samples; may reflect an inability to expel remaining amniotic fluid out of the lungs during or shortly after birth, or increased fluid accumulation (pulmonary edema) and/or tissue damage after lung injury" [MGI:anna] |
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Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011481 | anterior iris synechia | "adhesion of the iris to the cornea" [MGI:anna] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0011482 | posterior iris synechia | "adhesion of the iris to the capsule of the lens or to the surface of the vitreous body" [MGI:anna] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0011962 | increased cornea thickness | "increased width of the cornea in the center plane" [MGI:csmith] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0012113 | decreased inner cell mass proliferation | |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klf5tm1.1Jwel/Klf5tm1.1Jwel
Genetic Background: Not Specified
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| MP:0012117 | decreased trophectoderm cell proliferation | |
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klf5tm1.1Jwel/Klf5tm1.1Jwel
Genetic Background: Not Specified
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| MP:0013385 | abnormal Meibomian gland development | "aberrant formation or incomplete differentiation of the sebaceous glands located at the rim of the eyelids inside the tarsal plate and responsible for the supply of meibum, an oily substance that prevents evaporation of the eye s tear film; in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening" [PMID:20664693] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0013391 | abnormal Meibomian gland physiology | "any functional anomaly of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; dysfunctional Meibomian glands may produce an excessive amount of oil, cause dry eyes, or contribute to blepharitis" [MGI:Anna] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0013394 | abnormal palpebral conjunctiva morphology | "any structural anomaly of the thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies" [ISBN:0-683-40007] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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| MP:0013527 | absent conjunctiva goblet cells | "absence or failure to develop the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development" [MGI:Anna] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB
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| MP:0013754 | abnormal ocular surface morphology | "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB
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| MP:0014147 | lacrimal gland necrosis | "morphological changes resulting from pathological death of lacrimal gland tissue; usually due to irreversible damage" [MGI:Anna] |
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma
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