ENSMUSG00000000078


Mus musculus

Features
Gene ID: ENSMUSG00000000078
  
Biological name :Klf6
  
Synonyms : Klf6 / Kruppel like factor 6
  
Possible biological names infered from orthology : Q99612
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 5861482
Gene end: 5870394
  
Corresponding Affymetrix probe sets: 10403352 (MoGene1.0st)   1418280_at (Mouse Genome 430 2.0 Array)   1427742_a_at (Mouse Genome 430 2.0 Array)   1433508_at (Mouse Genome 430 2.0 Array)   1447448_s_at (Mouse Genome 430 2.0 Array)   1459718_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152088
Ensembl peptide - ENSMUSP00000000080
NCBI entrez gene - 23849     See in Manteia.
MGI - MGI:1346318
RefSeq - NM_011803
RefSeq Peptide - NP_035933
swissprot - A0A1Y7VLA9
swissprot - Q8BPQ2
Ensembl - ENSMUSG00000000078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf6aENSDARG00000029072Danio rerio
 KLF6ENSGALG00000033178Gallus gallus
 KLF6ENSG00000067082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*ENSMUSG0000002595949
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*ENSMUSG0000000514837
Klf1 / Kruppel like factor 1 / Q13351*ENSMUSG0000005419131
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*ENSMUSG0000007229431
Klf4 / Q60793 / Krueppel-like factor 4 / O43474* / Kruppel like factor 4*ENSMUSG0000000303231
Klf3 / Q60980 / Krueppel-like factor 3 / P57682* / Kruppel like factor 3*ENSMUSG0000002917829
Klf8 / Q8BLM0 / Krueppel-like factor 8 / O95600* / Kruppel like factor 8*ENSMUSG0000004164929
Klf2 / Q60843 / Krueppel-like factor 2 / Q9Y5W3* / Kruppel like factor 2*ENSMUSG0000005514829
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*ENSMUSG0000003008727
Gm12845ENSMUSG0000010812721
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*ENSMUSG0000004862620
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*ENSMUSG0000007090216


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
Show

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0009734 abnormal prostate gland duct morphology "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Klf6tm1Fjs/Klf6tm1Fjs,Nkx3-1tm3(cre)Mms/Nkx3-1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009736 abnormal prostate gland branching morphogenesis "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf6tm1Fjs/Klf6tm1Fjs,Nkx3-1tm3(cre)Mms/Nkx3-1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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