ENSMUSG00000003032


Mus musculus

Features
Gene ID: ENSMUSG00000003032
  
Biological name :Klf4
  
Synonyms : Klf4 / Krueppel-like factor 4 / Q60793
  
Possible biological names infered from orthology : Kruppel like factor 4 / O43474
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 55527143
Gene end: 55532466
  
Corresponding Affymetrix probe sets: 10513008 (MoGene1.0st)   1417394_at (Mouse Genome 430 2.0 Array)   1417395_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103245
Ensembl peptide - ENSMUSP00000123687
Ensembl peptide - ENSMUSP00000116514
NCBI entrez gene - 16600     See in Manteia.
MGI - MGI:1342287
RefSeq - NM_010637
RefSeq Peptide - NP_034767
swissprot - B7ZCH1
swissprot - F2YID5
swissprot - B7ZCH2
swissprot - Q60793
Ensembl - ENSMUSG00000003032
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf4ENSDARG00000079922Danio rerio
 KLF4ENSGALG00000026928Gallus gallus
 KLF4ENSG00000136826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf2 / Q60843 / Krueppel-like factor 2 / Q9Y5W3* / Kruppel like factor 2*ENSMUSG0000005514836
Klf1 / Kruppel like factor 1 / Q13351*ENSMUSG0000005419126
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*ENSMUSG0000000514823
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*ENSMUSG0000007229422
Klf8 / Q8BLM0 / Krueppel-like factor 8 / O95600* / Kruppel like factor 8*ENSMUSG0000004164922
Klf6 / Kruppel like factor 6 / Q99612*ENSMUSG0000000007820
Klf3 / Q60980 / Krueppel-like factor 3 / P57682* / Kruppel like factor 3*ENSMUSG0000002917820
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*ENSMUSG0000003008719
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*ENSMUSG0000002595918
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*ENSMUSG0000007090215
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*ENSMUSG0000004862614
Gm12845ENSMUSG0000010812714


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009913 epidermal cell differentiation IMP
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014740 negative regulation of muscle hyperplasia IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019827 stem cell population maintenance IDA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0031077 post-embryonic camera-type eye development IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion ISO
 biological_processGO:0035166 post-embryonic hemopoiesis IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045595 regulation of cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046985 positive regulation of hemoglobin biosynthetic process ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048679 regulation of axon regeneration IMP
 biological_processGO:0048730 epidermis morphogenesis IMP
 biological_processGO:0051247 positive regulation of protein metabolic process ISO
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060761 negative regulation of response to cytokine stimulus ISO
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus ISO
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071499 cellular response to laminar fluid shear stress ISO
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1904798 positive regulation of core promoter binding IMP
 biological_processGO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell ISO
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001010 transcription factor activity, sequence-specific DNA-binding transcription factor recruiting IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding NAS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000765 abnormal tongue squamous epithelium morphology "malformation of the scaly epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0001320 small pupils "smaller than normal size of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma

 MP:0003093 abnormal anterior stroma morphology "structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0003285 gastric hypertrophy "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm1Urt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004137 abnormal gastric surface mucous cells "malformation of the mucus secreting epithelial cells that lline the luminal surface of the stomach, gastric pits and gastric glands" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0004138 abnormal mucous neck cell morphology "malformation of the mucin-producing epithelial cells present in the the neck of the gastric glands " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0004481 abnormal conjunctival epithelium "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Dkc1tm1.1Pjma/Y
Genetic Background: B6.129X1(FVB)-Dkc1tm1.1Pjma

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0006307 abnormal seminiferous tubule size "alteration in the diameter of the tubules in the testes where spermatogenesis occurs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008521 abnormal Bowman membrane "any structural anomaly of the layer of acellular matrix that lies beneath the corneal epithelium and above the corneal stroma, consists of randomly arranged collagen fibers in a condensed bed of intercellular substance, and provides stability and strength to the cornea" [MESH:A09.371.060.217.113]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009612 thick epidermis suprabasal layer 
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0010203 focal ventral hair loss "focal hair loss on the ventral area of a rodent resulting in ventral skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Klf4tm1Efu/Klf4tm1Efu
Genetic Background: Not Specified

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012101 acoria "absence of the pupil of the eye" [MGI:anna]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0012110 increased hair follicle number "greater number of the epidermal invaginations from which the hair shaft develops" [MGI:monikat]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0013527 absent conjunctiva goblet cells "absence or failure to develop the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development" [MGI:Anna]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0013754 abnormal ocular surface morphology "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Klf5tm1Jaw/Klf5tm1Jaw,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0013765 iris hyperplasia "overdevelopment or increased size of the iris, usually due to an increased number of cells" [MGI:Anna]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0030577 increased keratinocyte adhesion "increased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Tg(Klf4-cre/ERT)1Wai/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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