ENSMUSG00000054191


Mus musculus

Features
Gene ID: ENSMUSG00000054191
  
Biological name :Klf1
  
Synonyms : Klf1 / Kruppel like factor 1
  
Possible biological names infered from orthology : Q13351
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 84901928
Gene end: 84905291
  
Corresponding Affymetrix probe sets: 10573457 (MoGene1.0st)   1418600_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064366
NCBI entrez gene - 16596     See in Manteia.
MGI - MGI:1342771
RefSeq - NM_010635
RefSeq Peptide - NP_034765
swissprot - E9QNP6
Ensembl - ENSMUSG00000054191
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf2aENSDARG00000042667Danio rerio
 klf2bENSDARG00000040432Danio rerio
 ENSGALG00000010101Gallus gallus
 KLF1ENSG00000105610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf4 / Q60793 / Krueppel-like factor 4 / O43474* / Kruppel like factor 4*ENSMUSG0000000303234
Klf2 / Q60843 / Krueppel-like factor 2 / Q9Y5W3* / Kruppel like factor 2*ENSMUSG0000005514831
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*ENSMUSG0000000514827
Klf6 / Kruppel like factor 6 / Q99612*ENSMUSG0000000007826
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*ENSMUSG0000007229425
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*ENSMUSG0000002595925
Klf8 / Q8BLM0 / Krueppel-like factor 8 / O95600* / Kruppel like factor 8*ENSMUSG0000004164924
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*ENSMUSG0000003008722
Klf3 / Q60980 / Krueppel-like factor 3 / P57682* / Kruppel like factor 3*ENSMUSG0000002917821
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*ENSMUSG0000004862618
Gm12845ENSMUSG0000010812718
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*ENSMUSG0000007090216


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR031784  Krueppel-like factor 1, transactivation domain 2
 IPR031786  Krueppel-like factor 1, transactivation domain 1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Nkx2-1tm2Shk/Nkx2-1tm2Shk
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Nkx2-1tm2Shk/Nkx2-1tm2Shk
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Klf1Nan/Klf1Nan
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Klf1Nan/Klf1+
Genetic Background: either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Klf1tm1Nimr/Klf1tm1Nimr
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Klf1Nan/Klf1Nan
Genetic Background: involves: 101/H * C3H/HeH * PT

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Klf1tm1Tow/Klf1tm1Tow,Tg(HBB)#Tow/0
Genetic Background: Not Specified

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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