ENSDARG00000042667


Danio rerio

Features
Gene ID: ENSDARG00000042667
  
Biological name :klf2a
  
Synonyms : klf2a / Kruppel-like factor 2a
  
Possible biological names infered from orthology : KLF1 / KLF2 / Krueppel-like factor 2 / Kruppel like factor 1 / Kruppel like factor 2 / Q13351 / Q60843 / Q9Y5W3
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 15898221
Gene end: 15900919
  
Corresponding Affymetrix probe sets: Dr.3448.1.S1_at (Zebrafish Array)   NM_131856_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000062586
NCBI entrez gene - 117508     See in Manteia.
RefSeq - NM_131856
RefSeq Peptide - NP_571931
swissprot - Q1LXI7
ZFIN ID - ZDB-GENE-011109-1
Ensembl - ENSDARG00000042667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000010101Gallus gallus
 KLF1ENSG00000105610Homo sapiens
 KLF2ENSG00000127528Homo sapiens
 Klf1ENSMUSG00000054191Mus musculus
 Klf2ENSMUSG00000055148Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
klf2b / Kruppel-like factor 2b / KLF1* / KLF2* / Q9Y5W3* / Q13351* / Kruppel like factor 1* / Kruppel like factor 2*ENSDARG0000004043255
klf17 / Kruppel-like factor 17ENSDARG0000003879243
klf1 / Kruppel-like factor 1 (erythroid)ENSDARG0000001740028
klf4 / Kruppel-like factor 4 / O43474*ENSDARG0000007992226
klf6a / Kruppel-like factor 6a / KLF6* / Q99612* / Kruppel like factor 6*ENSDARG0000002907225
klf7a / Kruppel-like factor 7a / KLF7* / Q99JB0* / O75840* / Kruppel like factor 7* / Krueppel-like factor 7 *ENSDARG0000007385724
klf5a / pibf1 / Kruppel-like factor 5a / KLF5* / Q9Z0Z7* / Q13887* / Kruppel like factor 5* / Krueppel-like factor 5 *ENSDARG0000001550624
klf7b / Kruppel-like factor 7b / KLF7* / Q99JB0* / O75840* / Kruppel like factor 7* / Krueppel-like factor 7 *ENSDARG0000004382124
klf5b / Kruppel-like factor 5b / KLF5* / Q9Z0Z7* / Q13887* / Kruppel like factor 5* / Krueppel-like factor 5 *ENSDARG0000006210623
klf15 / Kruppel-like factor 15 / Q9EPW2* / Q9UIH9* / Krueppel-like factor 15 *ENSDARG0000009112722
klf5l / Kruppel-like factor 5 likeENSDARG0000001875722
klf12b / Kruppel-like factor 12b / KLF12* / Q9Y4X4* / O35738* / Kruppel like factor 12* / Krueppel-like factor 12 *ENSDARG0000003219722
klf12a / Kruppel-like factor 12aENSDARG0000001531222
klf8 / Kruppel-like factor 8 / O95600* / Q8BLM0* / Krueppel-like factor 8 *ENSDARG0000006066121
klf3 / Kruppel-like factor 3 (basic) / P57682* / Q60980* / Kruppel like factor 3* / Krueppel-like factor 3 *ENSDARG0000001549521
klf6b / Kruppel-like factor 6bENSDARG0000003856120
si:ch211-117k10.3ENSDARG0000009091419


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0003171 atrioventricular valve development IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0006809 nitric oxide biosynthetic process IMP
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IGI
 biological_processGO:0042665 regulation of ectodermal cell fate specification IGI
 biological_processGO:0061444 endocardial cushion cell development IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000038 margin margin presumptive mesoderm differentiated , abnormal
Show

 ZFA:0000086 EVL EVL poorly differentiated , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus decreased amount , abnormal
Show

 ZFA:0001078 thymus thymus hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal morphology , abnormal
atrioventricular canal decreased amount , abnormal
Show

 ZFA:0001317 endocardial cushion endocardial cushion cell decreased amount , abnormal
Show

 ZFA:0001318 cardiac jelly cardiac jelly cell disorganized , abnormal
Show

 ZFA:0001345 interrenal gland interrenal gland animal organ morphogenesis process quality , abnormal
interrenal gland position , abnormal
interrenal gland epithelial to mesenchymal transition decreased occurrence , abnormal
Show

 ZFA:0005009 aortic arch 5 aortic arch 5 absent , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve morphology , abnormal
atrioventricular valve absent , abnormal
Show

 ZFA:0005802 interrenal angiogenic sprout interrenal angiogenic sprout decreased length , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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