ENSMUSG00000055148


Mus musculus

Features
Gene ID: ENSMUSG00000055148
  
Biological name :Klf2
  
Synonyms : Klf2 / Krueppel-like factor 2 / Q60843
  
Possible biological names infered from orthology : Kruppel like factor 2 / Q9Y5W3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 72319033
Gene end: 72321656
  
Corresponding Affymetrix probe sets: 10572800 (MoGene1.0st)   1448890_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064823
NCBI entrez gene - 16598     See in Manteia.
MGI - MGI:1342772
RefSeq - NM_008452
RefSeq Peptide - NP_032478
swissprot - Q60843
Ensembl - ENSMUSG00000055148
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf2aENSDARG00000042667Danio rerio
 klf2bENSDARG00000040432Danio rerio
 KLF2ENSG00000127528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf4 / Q60793 / Krueppel-like factor 4 / O43474* / Kruppel like factor 4*ENSMUSG0000000303249
Klf1 / Kruppel like factor 1 / Q13351*ENSMUSG0000005419133
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*ENSMUSG0000000514829
Klf6 / Kruppel like factor 6 / Q99612*ENSMUSG0000000007826
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*ENSMUSG0000007229426
Klf3 / Q60980 / Krueppel-like factor 3 / P57682* / Kruppel like factor 3*ENSMUSG0000002917825
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*ENSMUSG0000002595925
Klf8 / Q8BLM0 / Krueppel-like factor 8 / O95600* / Kruppel like factor 8*ENSMUSG0000004164924
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*ENSMUSG0000003008722
Gm12845ENSMUSG0000010812720
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*ENSMUSG0000004862619
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*ENSMUSG0000007090214


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IGI
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0060509 type I pneumocyte differentiation IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071499 cellular response to laminar fluid shear stress IEA
 biological_processGO:0097533 cellular stress response to acid chemical IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy5rtm1Aka/Npy5rtm1Aka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003394 increased cardiac output "greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0004879 decreased systemic vascular resistance "reduction in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Pgap1oto/Pgap1oto
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Klf2tm1Ling/Klf2tm1Ling
Genetic Background: involves: 129P2/OlaHsd

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Klf2tm1Mlkn/Klf2tm1Mlkn,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Klf2tm1Jml/Klf2tm1Jml
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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