ENSMUSG00000041649


Mus musculus

Features
Gene ID: ENSMUSG00000041649
  
Biological name :Klf8
  
Synonyms : Klf8 / Krueppel-like factor 8 / Q8BLM0
  
Possible biological names infered from orthology : Kruppel like factor 8 / O95600
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 153237466
Gene end: 153396132
  
Corresponding Affymetrix probe sets: 10602704 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000044317
Ensembl peptide - ENSMUSP00000108193
Ensembl peptide - ENSMUSP00000117653
NCBI entrez gene - 245671     See in Manteia.
MGI - MGI:2442430
RefSeq - XM_017318506
RefSeq - NM_173780
RefSeq - XM_011247821
RefSeq - XM_017318503
RefSeq - XM_017318504
RefSeq - XM_017318505
RefSeq - XM_006528852
RefSeq - XM_006528853
RefSeq - XM_006528858
RefSeq - XM_006528859
RefSeq - XM_006528860
RefSeq Peptide - NP_001344112
RefSeq Peptide - NP_776141
swissprot - Q8BLM0
swissprot - A6PWN1
Ensembl - ENSMUSG00000041649
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf8ENSDARG00000060661Danio rerio
 ENSGALG00000044078Gallus gallus
 KLF8ENSG00000102349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*ENSMUSG0000007229445
Klf3 / Q60980 / Krueppel-like factor 3 / P57682* / Kruppel like factor 3*ENSMUSG0000002917834
Klf4 / Q60793 / Krueppel-like factor 4 / O43474* / Kruppel like factor 4*ENSMUSG0000000303230
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*ENSMUSG0000000514829
Klf6 / Kruppel like factor 6 / Q99612*ENSMUSG0000000007826
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*ENSMUSG0000003008725
Klf1 / Kruppel like factor 1 / Q13351*ENSMUSG0000005419125
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*ENSMUSG0000002595925
Klf2 / Q60843 / Krueppel-like factor 2 / Q9Y5W3* / Kruppel like factor 2*ENSMUSG0000005514824
Gm12845ENSMUSG0000010812720
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*ENSMUSG0000004862617
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*ENSMUSG0000007090216


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016235 aggresome ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1.1Ctr/Mapk7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Klf8Gt(AD0101)Wtsi/Klf8Gt(AD0101)Wtsi
Genetic Background: FVB.129P2-Klf8Gt(AD0101)Wtsi

Allelic Composition: Klf8Gt(AD0101)Wtsi/Klf8+
Genetic Background: FVB.129P2-Klf8Gt(AD0101)Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Klf8Gt(AD0101)Wtsi/Klf8Gt(AD0101)Wtsi
Genetic Background: FVB.129P2-Klf8Gt(AD0101)Wtsi

Allelic Composition: Klf3tm1Merc/Klf3tm1Merc,Klf8Gt(AD0101)Wtsi/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Klf3tm1Merc/Klf3tm1Merc,Klf8Gt(AD0101)Wtsi/Klf8+
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Klf8Gt(AD0101)Wtsi/Klf8Gt(AD0101)Wtsi
Genetic Background: FVB.129P2-Klf8Gt(AD0101)Wtsi

Allelic Composition: Klf3tm1Merc/Klf3tm1Merc,Klf8Gt(AD0101)Wtsi/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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