Manteia

ENSMUSG00000029178

Mus musculus

Features

Gene ID:	ENSMUSG00000029178

Biological name :	Klf3

Synonyms :	Klf3 / Krueppel-like factor 3 / Q60980

Possible biological names infered from orthology :	Kruppel like factor 3 / P57682

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	C3.1
Gene start:	64803388
Gene end:	64832901

Corresponding Affymetrix probe sets:	10522051 (MoGene1.0st) 1421604_a_at (Mouse Genome 430 2.0 Array) 1429360_at (Mouse Genome 430 2.0 Array) 1431630_a_at (Mouse Genome 430 2.0 Array) 1441200_at (Mouse Genome 430 2.0 Array) 1442920_at (Mouse Genome 430 2.0 Array) 1454666_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000129363 Ensembl peptide - ENSMUSP00000142668 Ensembl peptide - ENSMUSP00000142651 Ensembl peptide - ENSMUSP00000142369 Ensembl peptide - ENSMUSP00000128429 NCBI entrez gene - 16599 See in Manteia. MGI - MGI:1342773 RefSeq - XM_006503751 RefSeq - NM_008453 RefSeq Peptide - NP_032479 swissprot - A0A0G2JE66 swissprot - A0A0G2JE81 swissprot - Q545J5 swissprot - Q60980 swissprot - A0A0G2JDH4 Ensembl - ENSMUSG00000029178

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
klf3	ENSDARG00000015495	Danio rerio
KLF3	ENSGALG00000041717	Gallus gallus
KLF3	ENSG00000109787	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Klf12 / O35738 / Krueppel-like factor 12 / Q9Y4X4* / Kruppel like factor 12*	ENSMUSG00000072294	46
Klf8 / Q8BLM0 / Krueppel-like factor 8 / O95600* / Kruppel like factor 8*	ENSMUSG00000041649	35
Klf5 / Q9Z0Z7 / Krueppel-like factor 5 / Q13887* / Kruppel like factor 5*	ENSMUSG00000005148	31
Klf4 / Q60793 / Krueppel-like factor 4 / O43474* / Kruppel like factor 4*	ENSMUSG00000003032	28
Klf6 / Kruppel like factor 6 / Q99612*	ENSMUSG00000000078	27
Klf2 / Q60843 / Krueppel-like factor 2 / Q9Y5W3* / Kruppel like factor 2*	ENSMUSG00000055148	26
Klf7 / Q99JB0 / Krueppel-like factor 7 / O75840* / Kruppel like factor 7*	ENSMUSG00000025959	24
Klf1 / Kruppel like factor 1 / Q13351*	ENSMUSG00000054191	23
Klf15 / Q9EPW2 / Krueppel-like factor 15 / Q9UIH9* / Kruppel like factor 15*	ENSMUSG00000030087	21
Klf17 / Q8CFA7 / Krueppel-like factor 17 / Q5JT82* / Kruppel like factor 17*	ENSMUSG00000048626	19
Gm12845	ENSMUSG00000108127	19
Zfp352 / zinc finger protein 352 / KLF18* / Kruppel like factor 18*	ENSMUSG00000070902	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:1901653	cellular response to peptide	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IC
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	ISS
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000233	abnormal blood flow velocity	"anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^m1Cmhd/Klf3⁺ Genetic Background: involves: BALB/cJ * C3H/HeJ * C57BL/6J Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001596	hypotension	"sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi} Genetic Background: FVB.129P2-Klf8^{Gt(AD0101)Wtsi}
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myo1e^tm1.1Flv/Myo1e^tm1.1Flv Genetic Background: involves: 129S6/SvEvTac
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002843	decreased blood pressure	"decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003394	increased cardiac output	"greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003808	enlarged endocardial cushions	"larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003922	abnormal right atrium morphology	"structural anomaly of the right upper chamber of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003923	abnormal left atrium morphology	"structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004876	decreased mean arterial blood pressure	"decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005076	abnormal cell differentiation	"anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005335	abnormal gonadal fat pad	"malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0005337	abnormal retroperitoneal fat pad	"malformed or aberrant size of the encapsulated adipose tissue found on the dorsal side of the peritoneum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005599	increased cardiac muscle contractility	"greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006044	tricuspid valve insufficiency	"the tricuspid valve does not close tightly enough to prevent leakage" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006048	pulmonary valve insufficiency	"the pulmonary valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006117	aortic valve stenosis	"abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0008726	enlarged left atrium	"increased size of the left upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0008727	enlarged right atrium	"increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0008817	hematoma	"an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0009287	decreased abdominal fat pad weight	"less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010127	hypervolemia	"an abnormally increased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^m1Cmhd/Klf3^m1Cmhd Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0010499	abnormal ventricle myocardium morphology	"any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^m1Cmhd/Klf3^m1Cmhd Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0010563	increased heart right ventricle size	"greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010593	thick aortic valve cusps	"an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010695	abnormal blood pressure regulation	"any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Sox5^tm2Vlf/Sox5^tm2Vlf,Sox6^tm2.1Vlf/Sox6^tm2.1Vlf,Tg(Prrx1-cre)1Cjt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Klf3^m1Cmhd/Klf3^m1Cmhd Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi} Genetic Background: FVB.129P2-Klf8^{Gt(AD0101)Wtsi} Allelic Composition: Klf3^tm1Merc/Klf3^tm1Merc,Klf8^{Gt(AD0101)Wtsi}/Y Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi} Genetic Background: FVB.129P2-Klf8^{Gt(AD0101)Wtsi} Allelic Composition: Klf3^tm1Merc/Klf3^tm1Merc,Klf8^{Gt(AD0101)Wtsi}/Klf8⁺ Genetic Background: involves: 129P2/OlaHsd * FVB/NJ Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011111	complete lethality during fetal growth through weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Klf8^{Gt(AD0101)Wtsi}/Klf8^{Gt(AD0101)Wtsi} Genetic Background: FVB.129P2-Klf8^{Gt(AD0101)Wtsi} Allelic Composition: Klf3^tm1Merc/Klf3^tm1Merc,Klf8^{Gt(AD0101)Wtsi}/Y Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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