ENSG00000127528


Homo sapiens

Features
Gene ID: ENSG00000127528
  
Biological name :KLF2
  
Synonyms : KLF2 / Kruppel like factor 2 / Q9Y5W3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 16324817
Gene end: 16327874
  
Corresponding Affymetrix probe sets: 219371_s_at (Human Genome U133 Plus 2.0 Array)   226645_at (Human Genome U133 Plus 2.0 Array)   226646_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000248071
Ensembl peptide - ENSP00000465035
NCBI entrez gene - 10365     See in Manteia.
OMIM - 602016
RefSeq - NM_016270
RefSeq Peptide - NP_057354
swissprot - Q9Y5W3
swissprot - K7EJ60
Ensembl - ENSG00000127528
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf2aENSDARG00000042667Danio rerio
 klf2bENSDARG00000040432Danio rerio
 Klf2ENSMUSG00000055148Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLF4 / O43474 / Kruppel like factor 4ENSG0000013682651
KLF1 / Q13351 / Kruppel like factor 1ENSG0000010561037
KLF5 / Q13887 / Kruppel like factor 5ENSG0000010255429
KLF12 / Q9Y4X4 / Kruppel like factor 12ENSG0000011892226
KLF8 / O95600 / Kruppel like factor 8ENSG0000010234925
KLF3 / P57682 / Kruppel like factor 3ENSG0000010978725
KLF7 / O75840 / Kruppel like factor 7ENSG0000011826325
KLF6 / Q99612 / Kruppel like factor 6ENSG0000006708225
KLF15 / Q9UIH9 / Kruppel like factor 15ENSG0000016388424
KLF17 / Q5JT82 / Kruppel like factor 17ENSG0000017187222
KLF18 / Kruppel like factor 18ENSG0000028303918


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0034101 erythrocyte homeostasis IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IMP
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051247 positive regulation of protein metabolic process IGI
 biological_processGO:0060509 type I pneumocyte differentiation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071498 cellular response to fluid shear stress IMP
 biological_processGO:0071499 cellular response to laminar fluid shear stress IMP
 biological_processGO:0097533 cellular stress response to acid chemical IMP
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IMP
 cellular_componentGO:0000790 nuclear chromatin IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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