ENSG00000136826


Homo sapiens

Features
Gene ID: ENSG00000136826
  
Biological name :KLF4
  
Synonyms : KLF4 / Kruppel like factor 4 / O43474
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q31.2
Gene start: 107484852
Gene end: 107490482
  
Corresponding Affymetrix probe sets: 220266_s_at (Human Genome U133 Plus 2.0 Array)   221841_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399921
Ensembl peptide - ENSP00000483629
Ensembl peptide - ENSP00000404922
Ensembl peptide - ENSP00000363804
NCBI entrez gene - 9314     See in Manteia.
OMIM - 602253
RefSeq - NM_001314052
RefSeq - NM_004235
RefSeq Peptide - NP_001300981
RefSeq Peptide - NP_004226
swissprot - Q5T3J6
swissprot - A0A087X0S4
swissprot - O43474
swissprot - B7ZBT2
Ensembl - ENSG00000136826
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf4ENSDARG00000079922Danio rerio
 KLF4ENSGALG00000026928Gallus gallus
 Klf4ENSMUSG00000003032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLF2 / Q9Y5W3 / Kruppel like factor 2ENSG0000012752838
KLF1 / Q13351 / Kruppel like factor 1ENSG0000010561027
KLF5 / Q13887 / Kruppel like factor 5ENSG0000010255423
KLF12 / Q9Y4X4 / Kruppel like factor 12ENSG0000011892221
KLF8 / O95600 / Kruppel like factor 8ENSG0000010234921
KLF3 / P57682 / Kruppel like factor 3ENSG0000010978721
KLF6 / Q99612 / Kruppel like factor 6ENSG0000006708220
KLF15 / Q9UIH9 / Kruppel like factor 15ENSG0000016388420
KLF18 / Kruppel like factor 18ENSG0000028303918
KLF7 / O75840 / Kruppel like factor 7ENSG0000011826318
KLF17 / Q5JT82 / Kruppel like factor 17ENSG0000017187217


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007500 mesodermal cell fate determination TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009913 epidermal cell differentiation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014740 negative regulation of muscle hyperplasia IEA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031077 post-embryonic camera-type eye development IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IMP
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IDA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0035166 post-embryonic hemopoiesis IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046985 positive regulation of hemoglobin biosynthetic process IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048679 regulation of axon regeneration IEA
 biological_processGO:0048730 epidermis morphogenesis IEA
 biological_processGO:0050728 negative regulation of inflammatory response TAS
 biological_processGO:0051247 positive regulation of protein metabolic process IGI
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IDA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071499 cellular response to laminar fluid shear stress IMP
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IGI
 biological_processGO:1904798 positive regulation of core promoter binding IEA
 biological_processGO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell IGI
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA
 biological_processGO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001010 transcription factor activity, sequence-specific DNA-binding transcription factor recruiting IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and deacylation of Ghrelin
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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