Manteia

ENSMUSG00000016255

Mus musculus

Features

Gene ID:	ENSMUSG00000016255

Biological name :	Tubb1

Synonyms :	A2AQ07 / Tubb1 / tubulin, beta 1 class VI

Possible biological names infered from orthology :	Q9H4B7

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	H4
Gene start:	174450695
Gene end:	174457882

Corresponding Affymetrix probe sets:	10479154 (MoGene1.0st) 1444214_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000016399 NCBI entrez gene - 545486 See in Manteia. MGI - MGI:107814 RefSeq - NM_001080971 RefSeq Peptide - NP_001074440 swissprot - A2AQ07 Ensembl - ENSMUSG00000016255

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9CWF2 / Tubb2b / tubulin, beta 2B class IIB / Q9BVA1*	ENSMUSG00000045136	78
Tubb3 / Q9ERD7 / tubulin, beta 3 class III / Q13509*	ENSMUSG00000062380	78
Q9D6F9 / Tubb4a / tubulin, beta 4A class IVA / P04350*	ENSMUSG00000062591	78
P68372 / Tubb4b / tubulin, beta 4B class IVB / P68371*	ENSMUSG00000036752	78
Q7TMM9 / Tubb2a / tubulin, beta 2A class IIA / Q13885*	ENSMUSG00000058672	78
Tubb6 / Q922F4 / tubulin, beta 6 class V / Q9BUF5*	ENSMUSG00000001473	78
Tubb5 / P99024 / tubulin, beta 5 class I / TUBB* / P07437* / tubulin beta class I*	ENSMUSG00000001525	77
Tube1 / Q9D6T1 / epsilon-tubulin 1 / Q9UJT0* / tubulin epsilon 1*	ENSMUSG00000019845	31
Tubd1 / Q9R1K7 / tubulin, delta 1 / Q9UJT1*	ENSMUSG00000020513	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR000217	Tubulin
IPR002453	Beta tubulin
IPR003008	Tubulin/FtsZ, GTPase domain
IPR008280	Tubulin/FtsZ, C-terminal
IPR013838	Beta tubulin, autoregulation binding site
IPR017975	Tubulin, conserved site
IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
IPR036525	Tubulin/FtsZ, GTPase domain superfamily
IPR037103	Tubulin/FtsZ, C-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007017	microtubule-based process	IDA
biological_process	GO:0051225	spindle assembly	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005874	microtubule	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005200	structural constituent of cytoskeleton	IDA
molecular_function	GO:0005525	GTP binding	IEA

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm Genetic Background: C.129S2(B6)-Cxcr2^tm1Mwm/J
MP:0003405	abnormal platelet shape		Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm Genetic Background: C.129S2(B6)-Cxcr2^tm1Mwm/J Allelic Composition: Tubb1^tm1Shiv/Tubb1^tm1Shiv Genetic Background: Not Specified
MP:0005464	abnormal platelet physiology	"atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv
MP:0005606	increased bleeding time	"greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm Genetic Background: C.129S2(B6)-Cxcr2^tm1Mwm/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr