ENSMUSG00000045136


Mus musculus

Features
Gene ID: ENSMUSG00000045136
  
Biological name :Tubb2b
  
Synonyms : Q9CWF2 / Tubb2b / tubulin, beta 2B class IIB
  
Possible biological names infered from orthology : Q9BVA1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 34126748
Gene end: 34130466
  
Corresponding Affymetrix probe sets: 10399419 (MoGene1.0st)   10408613 (MoGene1.0st)   1449682_s_at (Mouse Genome 430 2.0 Array)   1452679_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075178
NCBI entrez gene - 73710     See in Manteia.
MGI - MGI:1920960
RefSeq - NM_023716
RefSeq Peptide - NP_076205
swissprot - B2RSN3
swissprot - Q9CWF2
Ensembl - ENSMUSG00000045136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubb2ENSDARG00000039522Danio rerio
 Q9BVA1ENSG00000137285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TMM9 / Tubb2a / tubulin, beta 2A class IIA / Q13885*ENSMUSG00000058672100
P68372 / Tubb4b / tubulin, beta 4B class IVB / P68371*ENSMUSG0000003675297
Q9D6F9 / Tubb4a / tubulin, beta 4A class IVA / P04350*ENSMUSG0000006259196
Tubb5 / P99024 / tubulin, beta 5 class I / TUBB* / P07437* / tubulin beta class I*ENSMUSG0000000152596
Tubb3 / Q9ERD7 / tubulin, beta 3 class III / Q13509*ENSMUSG0000006238092
Tubb6 / Q922F4 / tubulin, beta 6 class V / Q9BUF5*ENSMUSG0000000147391
Tubb1 / A2AQ07 / tubulin, beta 1 class VI / Q9H4B7*ENSMUSG0000001625579
Tube1 / Q9D6T1 / epsilon-tubulin 1 / Q9UJT0* / tubulin epsilon 1*ENSMUSG0000001984533
Tubd1 / Q9R1K7 / tubulin, delta 1 / Q9UJT1*ENSMUSG0000002051323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration ISO
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:1902669 positive regulation of axon guidance ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
Hedgehog on state
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

Allelic Composition: Tubb2bbrdp/Tubb2b+
Genetic Background: involves: A/J * FVB

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic Background: Not Specified

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubb2bbrdp/Tubb2b+
Genetic Background: involves: A/J * FVB

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Tubb2bbrdp/Tubb2bbrdp
Genetic Background: involves: A/J * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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